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Human Polyclonal ARHGEF1 Primary Antibody for WB - ABIN2801964
Hart, Sharma, elMasry, Qiu, McCabe, Polakis, Bollag: Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. in The Journal of biological chemistry 1996
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Human Monoclonal ARHGEF1 Primary Antibody for IF, ELISA - ABIN522597
Zizer, Beilke, Bäuerle, Schilling, Möhnle, Adler, Fischer, Wagner: Loss of Lsc/p115 protein leads to neuronal hypoplasia in the esophagus and an achalasia-like phenotype in mice. in Gastroenterology 2010
Human Polyclonal ARHGEF1 Primary Antibody for ICC, IF - ABIN4281534
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Data suggest that MCP1/CCL2 (show CCL2 Antibodies) induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 inhibition suppresses MCP1 (show CCL2 Antibodies)-induced VSMC migration and proliferation. (ARHGEF1 = Rho guanine nucleotide exchange factor 1; RAC1 = Rac (show AKT1 Antibodies) family small GTPase (show RACGAP1 Antibodies) 1; CCL2 (show CCL2 Antibodies) = C-C motif chemokine ligand 2 (show CXCL2 Antibodies))
Data indicate that the crystal structure of PDZ-RhoGEF (show ARHGEF11 Antibodies) PDZ domain (show INADL Antibodies) in complex with the CXC chemokine receptor (show CXCR4 Antibodies) 2 (CXCR2 (show CXCR2 Antibodies)) C-terminal PDZ (show INADL Antibodies) binding motif.
We have reported here for the first time a reduced activity of both Rac1 and Cdc42 (show CDC42 Antibodies) in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1 (show FARP1 Antibodies), ARHGEF1, and ARHGAP36 (show ARHGAP36 Antibodies)
contactin-1 (show CNTN1 Antibodies) displayed the ability to phosphorylate the RhoA (show RHOA Antibodies) activator p115 RhoGEF
The novel role for p115RhoGEF in regulation of epithelial plasticity is dependent on Rho-DRF (show MPO Antibodies) signaling module.
Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).
Modification of p115RhoGEF at Serine(330) regulates its RhoGEF (show ARHGEF11 Antibodies) activity.
The action of DOCK7 (show DOCK7 Antibodies) in vivo may involve the coordinated integration of Cdc42 (show CDC42 Antibodies)/Rac1 signaling in the context of the membrane recruitment of a DOCK7 (show DOCK7 Antibodies) guanine nucleotide exchange factor (show RASGRF1 Antibodies) (GEF (show SLC2A4RG Antibodies)) complex.
High GEF1 expression is associated with metastasis of pancreatic cancer.
Activation of p115-RhoGEF requires direct association of Galpha13 (show GNA13 Antibodies) and the Dbl (show MCF2 Antibodies) homology domain.
Arhgef1 controls the process of neurite formation in newborn cortical neurons derived from neural progenitor cells
these findings reveal that Arhgef1 functions as a negative regulator of neurite outgrowth through regulating RhoA-cofilin pathway and actin dynamics.
Upon beta(2)AR activation, both betaArrestin2 and p115RhoGEF translocate to the plasma membrane, with concomitant activation of RhoA (show RHOA Antibodies) and formation of focal adhesions and stress fibers.
Thromboxane receptor (show TBXA2R Antibodies) signaling is required for fibronectin (show FN1 Antibodies)-induced matrix metalloproteinase 9 (show MMP9 Antibodies) production by human and murine macrophages and is attenuated by the Arhgef1 molecule.
Results show that PKC-alpha phosphorylation of p115RhoGEF mediates TNF-alpha signaling to RhoA, and that this plays a critical role in signaling F-actin rearrangement and barrier dysfunction in endothelial cells.
lsc/p115 (show ARHGAP4 Antibodies) deficiency results in impaired neuronal innervation and in motor dysfunction recapitulating several aspects of esophageal achalasia.
These data demonstrate that Arhgef1 regulates alpha5beta1-mediated MMP expression by macrophages and that loss of Arhgef1 by leukocytes leads to pulmonary pathology.
results show that control of RhoA (show RHOA Antibodies) signaling through Arhgef1 is central to the development of angiotensin II-dependent hypertension and identify Arhgef1 as a potential target for the treatment of hypertension
First, Lsc homo-oligomerizes and is negatively regulated through domains in its C terminus; and second, functionally distinct isoforms of Lsc lacking these domains are present in the spleen.
Lsc is essential for mediating TXA(2 (show TBXA2R Antibodies) )signaling involved in apoptosis and actin organization and suggest that TXA(2 (show TBXA2R Antibodies)) regulates thymic cellularity via Lsc.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
rho guanine nucleotide exchange factor (GEF) 1
, Rho guanine nucleotide exchange factor (GEF) 1
, rho guanine nucleotide exchange factor 1-like
, 115 kDa guanine nucleotide exchange factor
, 115-kD protein
, Lsc homolog
, rho guanine nucleotide exchange factor 1
, lbc's second cousin
, lymphoid blast crisis like 2
, lymphoid blast crisis-like 2