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A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis.
MCF2L is subject to a cis (show CISH Antibodies)-acting eQTL (show EQTN Antibodies) in synovial membrane that correlates with the OA association signal. This signal contains several functional SNPs that could account for the susceptibility and which therefore merit further investigation
In conclusion, we find that GDF5 (show GDF5 Antibodies), but not COG5 (show COG5 Antibodies) or MCF2L, influence the extent of radiographic damage in knee osteoarthritis
A single nucleotide polymorphism in MCF2L is associated with osteoarthritis.
Dbs is activated by Rac1 at the pleckstrin (show PLEK Antibodies) homology domain
the guanine nucleotide exchange factor Ost has a role in negative regulation of receptor endocytosis by the small GTPase Rac1
the PH domain of Dbs has a role in regulating Rho GTPase (show RACGAP1 Antibodies) activation
the PH domain of Dbs has two roles in the regulation of DH domain function, one for GTPase (show RACGAP1 Antibodies) association and activation in vitro and one for phosphoinositide binding and GTPase (show RACGAP1 Antibodies) interaction in vivo, that together promote Dbs association with membranes.
Dbs has the potential to promote proliferation of immature thymocytes, but also sensitizes immature thymocytes to deletion.
Crystal structure of the DH/PH fragment of Dbs without bound GTPase (show RACGAP1 Antibodies)
the Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein
Dbs transformation is associated with increased phosphorylation of myosin light chain and stress fiber formation, both of which occur in a ROCK-dependent manner
oncogene that can activate small GTP-binding proteins
DBL's big sister
, MCF2 transforming sequence-like protein
, guanine nucleotide exchange factor DBS
, MCF2-transforming sequence-like protein
, OST oncogene
, mcf.2 transforming sequence-like
, MCF.2 cell line derived transforming sequence-like
, coagulation factor VII
, guanine nucleotide exchange factor DBS-like
, Ost gamma
, exchange factor for RhoA and Cdc42
, guanine nucleotide exchange factor OSTIII