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This study identifies a novel regulatory crosstalk between Ral and Arf6 (show ARF6 Proteins) that controls Ral function in cells.
striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB (show Ralb Proteins).
RalA activation was remarkably impaired in rac1-deficient skeletal muscle fibres.
Our results provide the first in vivo characterization of RalA function in the mammalian brain and highlight a novel molecular mechanism for cell polarization.
The constitutively increased RalA activity occludes further increases in RalA activity during induction of long-term depression, causing impaired NMDAR (show GRIN1 Proteins)-long-term depression.
findings show either RALA or RALB (show Ralb Proteins) is sufficient for tumor growth; either RALA or RALB (show Ralb Proteins) is sufficient for cell proliferation; RALA and RALB (show Ralb Proteins) act in a redundant fashion
study reports the identification and characterization of a Ral GAP complex (RG1 (show PPP1R3A Proteins), RGC2) that mediates the activation of RalA downstream of the PI 3 (show PI3 Proteins)-kinase/Akt (show AKT1 Proteins) pathway
A novel regulatory pathway involves RalA and phospholipase D in the production of phosphatidic acid during Fc gamma receptor (show FCGR1A Proteins)-mediated phagocytosis and phagosome formation.
RalA but not RalB (show Ralb Proteins) mediates integrin-dependent membrane raft exocytosis through the exocyst complex. Constitutively active RalA restores membrane raft targeting to promote anchorage-independent growth signaling.
RalA activation elicited by the exchange factor RalGDS (show RALGDS Proteins) in response to a rise in intracellular Ca2 (show CA2 Proteins)+ and cAMP controls hormone release from pancreatic beta-cells
High RalA expression is associated with chronic myelogenous leukemia.
This study demonstrated that RalA is overactivated in medulloblastoma.
Study shows the additional benefits of anti-RalA autoantibody as a potential serological biomarker for prostate cancer (PCa (show FLVCR1 Proteins)), particularly in patients with normal PSA (show PLAG1 Proteins), and further demonstrate the utility of biomarker combinations in the immunodiagnosis of PCa (show FLVCR1 Proteins).
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of the D2R and D3R, through GRK2 and beta-arrestins, respectively. Active RalA was found to interact with GRK2 to sequester it from D2R. Knockdown of FLNA or coexpression of active RalA prevented D3R from coupling with G protein.
results suggest that the small GTPase (show RACGAP1 Proteins) RalA plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (show CAV1 Proteins) and FilA but by stimulating PLD2 (show PLD2 Proteins)-mediated generation of phosphatidic acid.
agonist-induced Gbetagamma-mediated conversion of RalA from the GTP (show AK3 Proteins)-bound form to the GDP-bound form could be a mechanism to facilitate agonist-induced internalization of GPCRs.
RCC2 (show RCC2 Proteins) exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase (show RACGAP1 Proteins) RalA. RCC2 (show RCC2 Proteins) and RalA apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis.
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
RAS-like, family 1
, ral-A protein
, ras-related protein Ral-A
, -ral simian leukemia viral oncogene homolog A (ras related)
, RAS-like protein A
, Ras family small GTP binding protein RALA
, ras related v-ral simian leukemia viral oncogene homolog A