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sortilin negatively regulates TGF-beta (show TGFB1 Proteins) signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
The SNP rs17646665, located in a non-coding region of the SORT1 gene, remained significantly associated with decreased risk of Alzheimer's disease after multiple testing (pc = 0.0061). In addition, other SNPs were found to be nominally associated with risk of Alzheimer's disease, as well as altered cognitive function and the CSF (show CSF2 Proteins) biomarker Abeta42, but these associations did not survive correction for multiple testing.
Sortilin was overexpressed in thyroid cancers compared with benign thyroid tissues
Authors provide evidence that Mn-induced exit of GPP130 (show GOLIM4 Proteins) from the trans-Golgi network (TGN (show TG Proteins)) toward lysosomes is mediated by the sorting receptor sortilin interacting with the lumenal stem domain of GPP130 (show GOLIM4 Proteins).
The longitudinal quantification of the serum sortilin-derived propeptide concentration could assist psychiatrists in the diagnosis of antidepressant response efficacy
Both circulating SORT1 and PCSK9 (show PCSK9 Proteins) levels are elevated in coronary artery disease patients.
Soluble sortilin exists in cerebrospinal fluid (CSF (show CSF2 Proteins)) in ten-fold molar excess compared to progranulin (show GRN Proteins) and observed a highly significant positive correlation between soluble sortilin and progranulin (show GRN Proteins) levels in CSF (show CSF2 Proteins) but not in plasma. The carriers of the minor allele of SNP rs646776 in SORT1 encoding sortilin displayed significantly increased soluble sortilin and reduced progranulin (show GRN Proteins) specifically in plasma but not in CSF (show CSF2 Proteins).
SORT1 single nucleotide polymorphism and it's association with LDL cholesterol level and risk of coronary heart disease in Pakistani population
Four SNPs within the APOE (show APOE Proteins) cluster (rs7412, rs4420638), ABCC2 (show ABCC2 Proteins) (rs2002042) and CELSR/SORT1/PSRC1 (show PSRC1 Proteins) (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80
In older men, higher serum sortilin levels associated with higher major adverse cerebrovascular/cardiovascular disease risk and severe abdominal aortic calcification.
sortilin is a PIP3 binding protein with binding likely to occur at the C-terminal neurotensin (show NTS Proteins) binding site, and is a competitor of neurotensin (show NTS Proteins)
findings provide insights into the posttranslational regulation of cytokine production through the posttranscriptional control of sortilin expression by TLR signals.
We showed that expression levels for NTS (show NTS Proteins) and NTSR1 (show NTSR1 Proteins) varied, that NTSR2 (show NTSR2 Proteins) expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined.
our findings indicate that sortilin is a beneficial protein for the reduction of amyloid pathology in APP (show APP Proteins)/PS1 (show PSEN1 Proteins) mice by promoting APP (show APP Proteins) degradation
we identify interferon-gamma (IFN-gamma (show IFNG Proteins)) as the key inflammatory mediator controlling sortilin-1 levels
Data suggest that sortilin expression in both gastrocnemius and extensor digitorum longus muscle is down-regulated by 17-18h of fasting/food deprivation; pathological levels of high blood glucose, as in streptozotocin-induced diabetes, do not alter sortilin expression in skeletal muscle; sortilin expression is elevated during differentiation of myocyte cell line or in presence of high concentration of glucose.
Shh (show SHH Proteins) and Sort1 can interact at the level of the Golgi and that Sort1 directs Shh (show SHH Proteins) away from the pathways that promote its secretion.
By contrast, treatment with dexamethasone, which also induced insulin (show INS Proteins) resistance, was without effect on sortilin expression and PE production. As a putative bioactive peptide, we have evaluated its autocrine effect by the use of spadin on 3T3-L1 adipocytes by performing glucose uptake and signalling experiments. Any effect was measured on adipocytes indicating that the use of spadin as an antidepressant would have no side
Sortilin 1 (Sort1) knockout (KO) does not affect Western diet-induced obesity nor adipose fatty acid and ceramide concentrations.
sortilin regulates cholestatic liver damage and fibrosis via effects on both aSMase (show SMPD1 Proteins) activity and serum IL-6 (show IL6 Proteins).
This study demonstrated that Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior.
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes\; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p\; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
, 100 kDa NT receptor
, glycoprotein 95
, neurotensin receptor 3
, glycoprotein 110