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Human IKBKB Protein expressed in Wheat germ - ABIN1307638
Tai, Su, Ma, Lee: SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. in The Journal of biological chemistry 2009
crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A
K63-linked ubiquitination occurs in other kinases at sites homologous to K147 in IKKbeta, including K578 in BRAF V600E, which serves as an oncogenic driver in melanoma and other cancers.
Depletion of human IKK1, IKK2 or IKK1/2 leads to strongly impaired NF-kappaB activation. Only IKK1/2 double-deficient cells are sensitized to TNF-alpha induced cell death. Cell death is mediated independently on NF-kappaB via RIPK1.
data in the current study have revealed a novel role for IKKbeta in negatively regulating GADD45alpha protein stability and the contribution of p53-dependent IKKbeta reduction to mediating cancer cell apoptosis.
vaccinia viral protein B14-mediated inhibition of IkappaB kinase beta activation
The results demonstrate that the inhibition of miR-16 renders resistance to paclitaxel in vitro and in vivo by targeting IKBKB via NF-kappa B signaling pathway.
Expression of TAp63, IKKbeta and XBP1s is also increased in livers of obese patients with liver steatosis.
IKK2 and NF-kappaB are related to poor prognosis and are potential predictors of response to platinum-based chemotherapy in high grade serous carcinoma
These studies identify functional EREs in the IKKB promoter and identify IKKB as an ERalpha and NSC35446.HCl-regulated gene, and they suggest that NF-kappaB and IKKB, which were previously linked to antiestrogen resistance, are targets for NSC35446.HCl in reversing antiestrogen resistance.
Curcumin suppressed CXCL5 expression by direct inhibition of IKKbeta phosphorylation, and inhibition of p38 MAPK via induction of negative regulator MKP-1.
This study demonstrated that nerve injury-induced Csf1 upregulation was ameliorated indicating that IKK/NF-kappaBeta-dependent SGC activation induced Csf1 expression in sensory neurons.
Findings uncover a novel function for IKKbeta/mHTTx1 interactions in regulating IL-34 production, and implicate a role for IL-34 in non-cell-autonomous, microglial-dependent neurodegeneration in HD.
HOTAIR operates the action of IKKalpha, IKKbeta, IKKgamma in liver cancer stem cells
These results suggested that APN ameliorated endothelial inflammation and IR through ROS/IKKbeta pathway.
p300-dependent histone H3 acetylation and C/EBPbeta-regulated IKKbeta expression contribute to thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells.
EGFR/PI3K/Akt/mTOR/IKK-beta/NF-kappaB signaling promotes head and neck cancer progression.
our results illustrate a new direction in nitrosourea treatment, and reveal that the combination of ROS-inducing IKKbeta inhibitors with nitrosoureas can be potentially exploited for melanoma therapy
Smad7 expression in necrotizing enterocolitis macrophages interrupts TGF-beta signaling and promotes NF-kappaB-mediated inflammatory signaling in these cells through increased expression of IKK-beta
High IKBKB expression is associated with prostate cancer.
Akt2, Erk2, and IKK1/2 phosphorylate Bcl3, converting Bcl3 into a transcriptional coregulator by facilitating its recruitment to DNA.
Rare variants in IKBKB are associated with decreased waist-to-hip ratio in European-Americans.
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin-mediated NO production.
High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
IKKepsilon plays a key role in the development of valvular remodeling in an aortic valve stenosis model.
Hepatic overexpression of N-terminal transactivation domain TAp63 induces liver steatosis through IKKbeta activation and the induction of ER stress.
Astrocyte IKKbeta deletion following high-fat diet-but not before- reduced glucose intolerance and insulin resistance. Hypothalamic inflammation and astrocytosis were reduced in HFD-fed IKKbeta-AKO mice.
IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets.
NF-kappaB is the transcription factor in regulating many proinflammatory cytokine genes.
p55TNFR-IKK2-Ripk3 signalling orchestrates arthritogenic and death responses in synovial fibroblasts
Pulmonary inflammation due to lung-specific overexpression of IKK2ca was sufficient to increase circulating TNFalpha and IL-6 levels, adipose expression of Tnfalpha and Il-6 mRNA, aortic endothelial dysfunction, and systemic insulin resistance.
prolonged IKKbeta inhibition decimates circulating Tregs and improves Cytotoxic t lymphocytes responses when commenced after tumor vaccination, indicating that IKKbeta represents a druggable checkpoint.
Results reveal that IKKbeta activity prevents skin tumor development, and shed light on the complex nature of IKKbeta effects on cancer progression, as IKKbeta can both promote and prevent carcinogenesis depending on the cell type or molecular context.
IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
Chronic overnutrition and astrocytic IKKbeta/NF-kappaB upregulation similarly impaired astrocytic plasticity, leading to sustained shortening of high-order processes. In physiology, astrocytic IKKbeta/NF-kappaB upregulation resulted in early-onset effects, including glucose intolerance and blood pressure rise, and late-onset effects, including body weight and fat gain.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS- or IKKbeta-induced production of GM-CSF. These studies indicate a complex role for GSTP in modulating NF-kappaB, which may involve S-glutathionylation of IKK proteins, and interaction with NF-kappaB family members.
Myeloid ikkbeta gene deletion significantly reduced the percentage of CD4(+)/IFN-gamma(+) (Th1) and CD4(+)/IL-17(+) (Th17) cells
Pharmacological and genetic inhibition of IKKbeta decreased voluntary ethanol consumption, providing initial support for IKKbeta as a potential therapeutic target for alcohol abuse.
Myeloid IKKbeta deficiency prevents Western diet-induced obesity and visceral adiposity in females but not in males, and attenuates hyperglycemia, global insulin resistance, and non-alcoholic steatohepatitis in both genders. In contrast, all metabolic sequela including non-alcoholic steatohepatitis are aggravated by hepatocyte IKKbeta deficiency (IkbkbDeltahep) in male but not female mice.
lymphocyte-specific deletion of IKK2 or NEMO aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.
data clearly demonstrate that KLHL21 negatively regulates TNFalpha-activated NF-kappaB signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB regulation in cells.
Study used three experimental approaches to enhance the IKKbeta activity in the liver of obese mice and observed increased XBP1s activity, reduced endoplasmic reticulum stress, and a significant improvement in insulin sensitivity and consequently in glucose homeostasis.
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
, inhibitor of nuclear factor kappa-B kinase subunit beta
, inhibitor of nuclear factor kappa-B kinase subunit beta-like
, IKK-like protein
, LPS-responsive kinase
, cactus kinase
, deficient 5
, immune response
, lipopolysaccharide activated kinase
, mmune response deficient 5
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, nuclear factor NF-kappa-B inhibitor kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of kappa light chain gene enhancer in B cells, kinase beta