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Human IKBKB Protein expressed in Wheat germ - ABIN1307638
Tai, Su, Ma, Lee: SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. in The Journal of biological chemistry 2009
crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A
Expression of TAp63, IKKbeta and XBP1s is also increased in livers of obese patients with liver steatosis.
IKK2 and NF-kappaB (show NFKB1 Proteins) are related to poor prognosis and are potential predictors of response to platinum-based chemotherapy in high grade serous carcinoma
These studies identify functional EREs in the IKKB promoter and identify IKKB as an ERalpha (show ESR1 Proteins) and NSC35446.HCl-regulated gene, and they suggest that NF-kappaB (show NFKB1 Proteins) and IKKB, which were previously linked to antiestrogen resistance, are targets for NSC35446.HCl in reversing antiestrogen resistance.
Curcumin suppressed CXCL5 (show CXCL5 Proteins) expression by direct inhibition of IKKbeta phosphorylation, and inhibition of p38 MAPK (show MAPK14 Proteins) via induction of negative regulator MKP-1 (show DUSP1 Proteins).
This study demonstrated that nerve injury-induced Csf1 (show CSF1 Proteins) upregulation was ameliorated indicating that IKK (show CHUK Proteins)/NF-kappaBeta (show NFKB1 Proteins)-dependent SGC (show SGCB Proteins) activation induced Csf1 (show CSF1 Proteins) expression in sensory neurons.
Findings uncover a novel function for IKKbeta/mHTTx1 interactions in regulating IL-34 (show IL34 Proteins) production, and implicate a role for IL-34 (show IL34 Proteins) in non-cell-autonomous, microglial-dependent neurodegeneration in HD.
HOTAIR operates the action of IKKalpha (show CHUK Proteins), IKKbeta, IKKgamma (show IKBKG Proteins) in liver cancer stem cells
These results suggested that APN (show ANPEP Proteins) ameliorated endothelial inflammation and IR through ROS (show ROS1 Proteins)/IKKbeta pathway.
p300 (show EP300 Proteins)-dependent histone H3 (show HIST3H3 Proteins) acetylation and C/EBPbeta (show CEBPB Proteins)-regulated IKKbeta expression contribute to thrombin (show F2 Proteins)-induced IL-8/CXCL8 (show IL8 Proteins) expression in human lung epithelial cells.
EGFR (show EGFR Proteins)/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins)/IKK-beta/NF-kappaB (show NFKB1 Proteins) signaling promotes head and neck cancer progression.
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin (show PRL Proteins) in bovine mammary epithelial cells.
Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin (show INS Proteins)-mediated NO production.
High glucose-induced IKK (show CHUK Proteins)-Hsp-90 (show HSP90 Proteins) interaction contributes to endothelial dysfunction.
Hepatic overexpression of N-terminal transactivation domain TAp63 induces liver steatosis through IKKbeta activation and the induction of ER stress.
Astrocyte IKKbeta deletion following high-fat diet-but not before- reduced glucose intolerance and insulin (show INS Proteins) resistance. Hypothalamic inflammation and astrocytosis were reduced in HFD-fed IKKbeta-AKO mice.
IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets.
NF-kappaB (show NFKB1 Proteins) is the transcription factor in regulating many proinflammatory cytokine genes.
p55TNFR-IKK2-Ripk3 (show RIPK3 Proteins) signalling orchestrates arthritogenic and death responses in synovial fibroblasts
Pulmonary inflammation due to lung-specific overexpression of IKK2ca was sufficient to increase circulating TNFalpha (show TNF Proteins) and IL-6 (show IL6 Proteins) levels, adipose expression of Tnfalpha (show TNF Proteins) and Il-6 (show IL6 Proteins) mRNA, aortic endothelial dysfunction, and systemic insulin (show INS Proteins) resistance.
prolonged IKKbeta inhibition decimates circulating Tregs and improves Cytotoxic t lymphocytes responses when commenced after tumor vaccination, indicating that IKKbeta represents a druggable checkpoint.
Results reveal that IKKbeta activity prevents skin tumor development, and shed light on the complex nature of IKKbeta effects on cancer progression, as IKKbeta can both promote and prevent carcinogenesis depending on the cell type or molecular context.
IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
Chronic overnutrition and astrocytic IKKbeta/NF-kappaB (show NFKB1 Proteins) upregulation similarly impaired astrocytic plasticity, leading to sustained shortening of high-order processes. In physiology, astrocytic IKKbeta/NF-kappaB (show NFKB1 Proteins) upregulation resulted in early-onset effects, including glucose intolerance and blood pressure rise, and late-onset effects, including body weight and fat gain.
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
, inhibitor of nuclear factor kappa-B kinase subunit beta
, inhibitor of nuclear factor kappa-B kinase subunit beta-like
, IKK-like protein
, LPS-responsive kinase
, cactus kinase
, deficient 5
, immune response
, lipopolysaccharide activated kinase
, mmune response deficient 5
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, nuclear factor NF-kappa-B inhibitor kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of kappa light chain gene enhancer in B cells, kinase beta