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Human IKBKB Protein expressed in Wheat germ - ABIN1307638
Tai, Su, Ma, Lee: SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. in The Journal of biological chemistry 2009
crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A
These results suggested that APN (show ANPEP Proteins) ameliorated endothelial inflammation and IR through ROS (show ROS1 Proteins)/IKKbeta pathway.
p300 (show EP300 Proteins)-dependent histone H3 (show HIST3H3 Proteins) acetylation and C/EBPbeta (show CEBPB Proteins)-regulated IKKbeta expression contribute to thrombin (show F2 Proteins)-induced IL-8/CXCL8 (show IL8 Proteins) expression in human lung epithelial cells.
EGFR (show EGFR Proteins)/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins)/IKK-beta/NF-kappaB (show NFKB1 Proteins) signaling promotes head and neck cancer progression.
our results illustrate a new direction in nitrosourea treatment, and reveal that the combination of ROS (show ROS1 Proteins)-inducing IKKbeta inhibitors with nitrosoureas can be potentially exploited for melanoma therapy
Smad7 (show SMAD7 Proteins) expression in necrotizing enterocolitis macrophages interrupts TGF-beta (show TGFB1 Proteins) signaling and promotes NF-kappaB (show NFKB1 Proteins)-mediated inflammatory signaling in these cells through increased expression of IKK-beta
High IKBKB expression is associated with prostate cancer.
Akt2 (show AKT2 Proteins), Erk2 (show MAPK1 Proteins), and IKK1 (show CHUK Proteins)/2 phosphorylate Bcl3 (show BCL3 Proteins), converting Bcl3 (show BCL3 Proteins) into a transcriptional coregulator by facilitating its recruitment to DNA.
Rare variants in IKBKB are associated with decreased waist-to-hip ratio in European-Americans.
pVHL (show VHL Proteins) mediates K63-linked ubiquitination of IKKbeta, which plays a role in the regulation of IKK (show CHUK Proteins)/NF-kappaB (show NFKB1 Proteins) signalling.
N-acetyl-seryl-aspartyl-lysyl-proline inhibition of TNF-alpha (show TNF Proteins) activation of canonical, i.e., IKK-beta-dependent, NF-kappaB (show NFKB1 Proteins) pathway and subsequent decrease in ICAM-1 (show ICAM1 Proteins) expression is achieved via inhibition of IKK-beta.
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin (show PRL Proteins) in bovine mammary epithelial cells.
Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin (show INS Proteins)-mediated NO production.
High glucose-induced IKK (show CHUK Proteins)-Hsp-90 (show HSP90 Proteins) interaction contributes to endothelial dysfunction.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP (show GSTP1 Proteins) significantly attenuated LPS (show TLR4 Proteins)- or IKKbeta-induced production of GM-CSF (show CSF2 Proteins). These studies indicate a complex role for GSTP (show GSTP1 Proteins) in modulating NF-kappaB (show NFKB1 Proteins), which may involve S-glutathionylation of IKK (show CHUK Proteins) proteins, and interaction with NF-kappaB (show NFKB1 Proteins) family members.
Myeloid ikkbeta gene deletion significantly reduced the percentage of CD4 (show CD4 Proteins)(+)/IFN-gamma (show IFNG Proteins)(+) (Th1 (show HAND1 Proteins)) and CD4 (show CD4 Proteins)(+)/IL-17 (show IL17A Proteins)(+) (Th17) cells
Pharmacological and genetic inhibition of IKKbeta decreased voluntary ethanol consumption, providing initial support for IKKbeta as a potential therapeutic target for alcohol abuse.
Myeloid IKKbeta deficiency prevents Western diet-induced obesity and visceral adiposity in females but not in males, and attenuates hyperglycemia, global insulin (show INS Proteins) resistance, and non-alcoholic steatohepatitis in both genders. In contrast, all metabolic sequela including non-alcoholic steatohepatitis are aggravated by hepatocyte IKKbeta deficiency (IkbkbDeltahep) in male but not female mice.
lymphocyte-specific deletion of IKK2 or NEMO (show IKBKG Proteins) aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.
data clearly demonstrate that KLHL21 (show KLHL21 Proteins) negatively regulates TNFalpha (show TNF Proteins)-activated NF-kappaB (show NFKB1 Proteins) signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB (show NFKB1 Proteins) regulation in cells.
Study used three experimental approaches to enhance the IKKbeta activity in the liver of obese mice and observed increased XBP1s activity, reduced endoplasmic reticulum stress, and a significant improvement in insulin (show INS Proteins) sensitivity and consequently in glucose homeostasis.
Mutation of cysteine 46 in IKK-beta increases inflammatory responses.
TAK1 and IKK2 are novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.
MyD88s is positively regulated by IKKbeta and CREB and negatively regulated by ERK1/2 signaling pathways.
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
, inhibitor of nuclear factor kappa-B kinase subunit beta
, inhibitor of nuclear factor kappa-B kinase subunit beta-like
, IKK-like protein
, LPS-responsive kinase
, cactus kinase
, deficient 5
, immune response
, lipopolysaccharide activated kinase
, mmune response deficient 5
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, nuclear factor NF-kappa-B inhibitor kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of kappa light chain gene enhancer in B cells, kinase beta