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Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2007346
Dinarello: Biologic basis for interleukin-1 in disease. in Blood 1996
Show all 6 Pubmed References
the present study was intended to determine whether single-nucleotide polymorphisms (SNPs) in the IL-1 gene cluster are also associated with periodontal disease in a Linkage disequilibrium analysis
No significant difference was seen in mRNA levels among different promoter genotype for IL1A in SCA3 (show ATXN3 Proteins) patients vs. controls, except a previously reported higher level in those with the IL1A*T allele. These patients also showed an earlier age of onset than those homozygous for IL1A*C.
Obesity was associated with higher expression of NILCO molecules (Notch (show NOTCH1 Proteins)-IL1-leptin (show LEP Proteins)) in type II endometrial cancer.
through IL-1alpha production, airway epithelial cells induce a pro-inflammatory lung fibroblast phenotype that is further enhanced with cigarette smoke extract exposure in COPD (show ARCN1 Proteins), suggesting an aberrant epithelial-fibroblast interaction in COPD (show ARCN1 Proteins)
our study has described the association between rs3783550 (IL-1A), rs3783546 (IL-1A) and rs2853550 (IL-1B) and AS risk and between a new haplotype, "TCG", of rs3783550, rs3783546 and rs2853550 and AS in Chinese Han population.
In conclusion, the analyzed IL1A -889 C>T, IL1B (show IL1B Proteins) +3954 C>T, and IL6 (show IL6 Proteins) -174 G>C polymorphisms may be associated with the occurrence and development of human cytomegalovirus infection among studied patients.
Lipid apheresis suppresses the expression of IL-1alpha, IL-6 (show IL6 Proteins) and TNF-alpha (show TNF Proteins) mRNA in patients with dyslipidaemias.
results suggest a role for prostatic expression of TGF-B, IL-1a, TGFBRI and TGFBRII as prognostic markers for prostate cancer. The rational combination of novel agents directed toward the inactivation of TGF-B, IL-1a, TGFBRI and TGFBRII could disrupt complementary tumor cell proliferation pathways.
There were no significant differences in GE area of infertile and fertile women. C-C motif chemokine 11 (P=0.048), TGFalpha (P=0.049), IFNgamma (P=0.033) and interleukin-1 alpha (P=0.047) were significantly elevated in uterine lavage from infertile women <35years compared to fertile but not in women 35years
The authors' findings suggest that IL-1a rs3783553 polymorphism may modulate the risk of squamous cell carcinoma of the oropharynx recurrence in patients, particularly for patients with HPV16-positive tumors.
Together, these data suggest that caspase-11 (show CASP4 Proteins)/IL-1alpha pathway plays an important role in defending against Klebsiella pneumoniae by recruiting neutrophils in the early stage of infection.
These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A and Fshr (show FSHR Proteins) expression.
Following vasectomy, IL1alpha, IL1beta (show IL1B Proteins), IL1ra (show IL1RN Proteins), IL10 (show IL10 Proteins), and TNF-alpha (show TNF Proteins) may mediate immune reaction in whole epididymis, whereas IL6 (show IL6 Proteins) and TGF-beta1 (show TGFB1 Proteins) may mediate regionally different immune response primarily in the lower part of epididymis.
Since neither IL-1alpha nor IL-1beta (show IL1B Proteins) depletions completely rescued the phenotype, we believe that IL-1alpha and IL-1beta (show IL1B Proteins) have a similar and probably complementary role in FHF progression
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE (show AGER Proteins)-p38 MAPK (show MAPK14 Proteins) and calpain-1 (show CAPN1 Proteins) pathway in keratinocyte and this mechanism may play an important role during psoriasis.
Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.
endothelial cells were identified as the primary cellular source of G-CSF (show CSF3 Proteins) during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.
As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP (show DDIT3 Proteins) intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells.
These data demonstrate that DC and macrophages display distinct patterns of cytokine regulation, particularly with respect to IL-1, as a consequence of cell-type specific differences in the physicochemical properties of the P2X(7 (show P2RX7 Proteins))R
Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.
Testicular IL-1 alpha and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.
Genes for IL-1alpha and IL-1beta (show IL1B Proteins) are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta (show IL1B Proteins) may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties
These results suggest that IL-1alpha and IL-1beta (show IL1B Proteins) are produced by the stromal cells, that IL-1beta (show IL1B Proteins) is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen (show PLG Proteins) activator in bovine endometrial cells.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
, interleukin-1 alpha
, preinterleukin 1 alpha
, interleukin 1 alpha
, interleukin 1-alpha
, precursor interleukin 1 alpha
, Interleukin-1 alpha
, precursor interleukin-1alpha