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Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2007346
Dinarello: Biologic basis for interleukin-1 in disease. in Blood 1996
Show all 6 Pubmed References
Meta-analysis suggests that the IL-1B (show IL1B Proteins) rs16944 polymorphism is a susceptibility risk factor for febrile seizures in Caucasian and Asian populations. The IL-1B (show IL1B Proteins) rs1143627, IL-1B (show IL1B Proteins) rs1143634, and IL-1A rs1800587 polymorphisms are not associated with febrile seizure risk.
The IL-1b+3954 C/T polymorphism significantly increases RAS risk. In addition, the IL-10-1082 G/A polymorphism provided protective effects for RAS in the Asian population
The single nucleotide polymorphism (SNP) of IL-1beta (show IL1B Proteins) gene (rs3917356G>A) increased the risk of HCC (show FAM126A Proteins) in the recessive model (p<0.001, OR=2.58, 95% CI=1.53-4.33), whereas other SNPs in IL-1alpha and IL-1RA (show IL1RN Proteins) showed no significant association between Hepatocellular carcinoma patients and controls.
our findings proposed an association between IL1A 4-bp ins (show INS Proteins)/del polymorphism and risk of prostate cancer
effect of IL-22 (show IL22 Proteins) on Intestinal Epithelial Cells responses may not be in inducing CXCL8 (show IL8 Proteins) by itself, but in enhancing TNF-alpha (show TNF Proteins)- and IL-1-induced CXCL8 (show IL8 Proteins) secretion to augment the contribution of IECs to local inflammatory responses.
the present study was intended to determine whether single-nucleotide polymorphisms (SNPs) in the IL-1 gene cluster are also associated with periodontal disease in a Linkage disequilibrium analysis
No significant difference was seen in mRNA levels among different promoter genotype for IL1A in SCA3 (show ATXN3 Proteins) patients vs. controls, except a previously reported higher level in those with the IL1A*T allele. These patients also showed an earlier age of onset than those homozygous for IL1A*C.
Obesity was associated with higher expression of NILCO molecules (Notch (show NOTCH1 Proteins)-IL1-leptin (show LEP Proteins)) in type II endometrial cancer.
through IL-1alpha production, airway epithelial cells induce a pro-inflammatory lung fibroblast phenotype that is further enhanced with cigarette smoke extract exposure in COPD (show ARCN1 Proteins), suggesting an aberrant epithelial-fibroblast interaction in COPD (show ARCN1 Proteins)
our study has described the association between rs3783550 (IL-1A), rs3783546 (IL-1A) and rs2853550 (IL-1B) and AS risk and between a new haplotype, "TCG", of rs3783550, rs3783546 and rs2853550 and AS in Chinese Han population.
Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1 (show TGFB1 Proteins), and MMP1 (show MMP1 Proteins) in multinucleated macrophages.
Together, these data suggest that caspase-11 (show CASP4 Proteins)/IL-1alpha pathway plays an important role in defending against Klebsiella pneumoniae by recruiting neutrophils in the early stage of infection.
These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A and Fshr (show FSHR Proteins) expression.
Following vasectomy, IL1alpha, IL1beta (show IL1B Proteins), IL1ra (show IL1RN Proteins), IL10 (show IL10 Proteins), and TNF-alpha (show TNF Proteins) may mediate immune reaction in whole epididymis, whereas IL6 (show IL6 Proteins) and TGF-beta1 (show TGFB1 Proteins) may mediate regionally different immune response primarily in the lower part of epididymis.
Since neither IL-1alpha nor IL-1beta (show IL1B Proteins) depletions completely rescued the phenotype, we believe that IL-1alpha and IL-1beta (show IL1B Proteins) have a similar and probably complementary role in FHF progression
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE (show AGER Proteins)-p38 MAPK (show MAPK14 Proteins) and calpain-1 (show CAPN1 Proteins) pathway in keratinocyte and this mechanism may play an important role during psoriasis.
Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.
endothelial cells were identified as the primary cellular source of G-CSF (show CSF3 Proteins) during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.
As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP (show DDIT3 Proteins) intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells.
Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.
Testicular IL-1 alpha and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.
Genes for IL-1alpha and IL-1beta (show IL1B Proteins) are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta (show IL1B Proteins) may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties
These results suggest that IL-1alpha and IL-1beta (show IL1B Proteins) are produced by the stromal cells, that IL-1beta (show IL1B Proteins) is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen (show PLG Proteins) activator in bovine endometrial cells.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
, interleukin-1 alpha
, preinterleukin 1 alpha
, interleukin 1 alpha
, interleukin 1-alpha
, precursor interleukin 1 alpha
, Interleukin-1 alpha
, precursor interleukin-1alpha