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Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2007346
Dinarello: Biologic basis for interleukin-1 in disease. in Blood 1996
Show all 6 Pubmed References
Following vasectomy, IL1alpha, IL1beta (show IL1B Proteins), IL1ra (show IL1RN Proteins), IL10 (show IL10 Proteins), and TNF-alpha (show TNF Proteins) may mediate immune reaction in whole epididymis, whereas IL6 (show IL6 Proteins) and TGF-beta1 (show TGFB1 Proteins) may mediate regionally different immune response primarily in the lower part of epididymis.
Since neither IL-1alpha nor IL-1beta (show IL1B Proteins) depletions completely rescued the phenotype, we believe that IL-1alpha and IL-1beta (show IL1B Proteins) have a similar and probably complementary role in FHF progression
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
Our findings indicate that IL-1 plays an important role in skin lesions of systemic lupus erythematosus (SLE), suggesting that IL-1 is a therapeutic target in skin lesions of SLE.
our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE (show AGER Proteins)-p38 MAPK (show MAPK14 Proteins) and calpain-1 (show CAPN1 Proteins) pathway in keratinocyte and this mechanism may play an important role during psoriasis.
IL-1 and IL-36 have roles as inflammatory mediators in pustular psoriasis in a mouse model
These data demonstrate that IL-1 functions as a mitogenic mediator of encephalitogenic Th17 cells rather than qualitative inducer of their generation
Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.
endothelial cells were identified as the primary cellular source of G-CSF (show CSF3 Proteins) during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.
Studies indicate that SHP1 (show PTPN6 Proteins) and SYK (show SYK Proteins) crosstalk as a critical regulator of MyD88 (show MYD88 Proteins) post-translational modifications and IL-1-driven inflammation.
results suggest a role for prostatic expression of TGF-B, IL-1a, TGFBRI and TGFBRII as prognostic markers for prostate cancer. The rational combination of novel agents directed toward the inactivation of TGF-B, IL-1a, TGFBRI and TGFBRII could disrupt complementary tumor cell proliferation pathways.
There were no significant differences in GE area of infertile and fertile women. C-C motif chemokine 11 (P=0.048), TGFalpha (P=0.049), IFNgamma (P=0.033) and interleukin-1 alpha (P=0.047) were significantly elevated in uterine lavage from infertile women <35years compared to fertile but not in women 35years
The authors' findings suggest that IL-1a rs3783553 polymorphism may modulate the risk of squamous cell carcinoma of the oropharynx recurrence in patients, particularly for patients with HPV16-positive tumors.
Based on current meta-analysis, we indicated that there is lack of association between the three SNPs of IL-1 and primary open-angle glaucoma.
results showed that IL-1A -889C/T (rs1800587) was associated with systemic sclerosis susceptibility in the Chinese population
Reconstitution of ST2 (show SULT2A1 Proteins) (IL-1R4) specific for IL-33 (show IL33 Proteins) activity; no suppression by IL-1Ra (show IL1RN Proteins) though a common chain IL-1R3 (IL-1RAcP (show IL1RAP Proteins)) shared with IL-1.
A SNP in IL1A were associated with keratoconus in Chinese Han patients
these findings highlight the interaction between IL-6 and IL-1alpha to generate an inflammatory microenvironment in driving (PSMA,PSA) prostate clones
MSCs primed with IL-1alpha or IL-1beta (show IL1B Proteins) showed increased secretion of G-CSF (show CSF3 Proteins), which was blocked by IL-1Ra (show IL1RN Proteins).
rs3783553 ins/ins (show INS Proteins) genotype may increase the susceptibility to ischemic stroke, possibly by interrupting the binding site of miR (show MLXIP Proteins)-122 and miR (show MLXIP Proteins)-378
Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.
Testicular IL-1 alpha and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.
Genes for IL-1alpha and IL-1beta (show IL1B Proteins) are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta (show IL1B Proteins) may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties
These results suggest that IL-1alpha and IL-1beta (show IL1B Proteins) are produced by the stromal cells, that IL-1beta (show IL1B Proteins) is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen (show PLG Proteins) activator in bovine endometrial cells.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
, interleukin-1 alpha
, preinterleukin 1 alpha
, interleukin 1-alpha
, Interleukin-1 alpha
, precursor interleukin-1alpha
, interleukin 1 alpha
, precursor interleukin 1 alpha