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Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305081
Gray, Glaister, Chen, Goeddel, Pennica: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. in Journal of immunology (Baltimore, Md. : 1950) 1986
Show all 4 Pubmed References
Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1589581
Hollborn, Vogler, Reichenbach, Wiedemann, Bringmann, Kohen: Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. in Molecular vision 2015
Show all 2 Pubmed References
Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN413480
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 2 Pubmed References
Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305079
Kitamura, Tange, Terasawa, Chiba, Kuwaki, Miyagawa, Piao, Miyazono, Urabe, Takaku: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. in Journal of cellular physiology 1989
Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN988112
Zhang, Bennett, Verkman: Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. in Annals of neurology 2011
Rat (Rattus) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN809718
Yang, Poon, Luo, Cheung, Ho, Lo, Fan: Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway. in Journal of immunology (Baltimore, Md. : 1950) 2004
Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN804033
Tiwari, Wang, Brochetta, Ke, Vita, Qi, Rivera, Soranzo, Zabucchi, Hong, Blank: VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. in Blood 2008
This study reveals that proper levels of Il1b signaling and tissue inflammation, which are tuned by macrophages, play a crucial role in tissue regeneration.
Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase (show CASP3 Proteins) dependent manner.
Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.
findings reveal that the Il-1beta-Myd88 (show MYD88 Proteins) axis and NADPH oxidase (show NOX1 Proteins)-mediated ROS (show ROS1 Proteins) signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.
the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae
These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.
Chemokine receptor 2 (CCR2 (show CCR2 Proteins)(+)) monocytes invade the hippocampus between 1 and 3 d after SE. In contrast, only an occasional CD3 (show CD3E Proteins)(+) T lymphocyte was encountered 3 d after SE. The initial cellular sources of the chemokine (show CCL1 Proteins) CCL2 (show CCL2 Proteins), a ligand for CCR2 (show CCR2 Proteins), included perivascular macrophages and microglia. The induction of the proinflammatory cytokine IL-1beta was greater in FACS-isolated microglia than in brain-invading monocytes
hypernociception in experimental model of autoimmune encephalomyelitis may be a consequence of the increase in some cytokines in dorsal root ganglia, especially IL-1beta.
An OA model was established in mouse articular chondrocytes (MACs) treated by interleukin-1beta (IL-1beta).
The current study demonstrated that honey can stimulate or suppress the mRNA expression of some pro-inflammatory cytokines in mice brains. Furthermore, honey suppresses the TNF-alpha (show TNF Proteins) mRNA expression in the presence of T. gondii infection but it stimulates the IL-1beta and IL-6 (show IL6 Proteins) mRNA expression. Treatment of the mice with honey reduces parasite multiplication in the brain.
IL-1beta has a direct effect on NGAL (show LCN2 Proteins) production by tubular epithelial cells.
Following vasectomy, IL1alpha (show IL1A Proteins), IL1beta, IL1ra (show IL1RN Proteins), IL10 (show IL10 Proteins), and TNF-alpha (show TNF Proteins) may mediate immune reaction in whole epididymis, whereas IL6 (show IL6 Proteins) and TGF-beta1 (show TGFB1 Proteins) may mediate regionally different immune response primarily in the lower part of epididymis.
Elevations of CO2 cause oligomerization of the inflammasome components ASC (show STS Proteins), NLRP3 (show NLRP3 Proteins), caspase 1 (show CASP1 Proteins), thioredoxin interacting protein (show TXNIP Proteins), and calreticulin (show CALR Proteins) - a protein from endoplasmic reticulum, leading to IL-1beta synthesis. An increased production rate of MPs containing elevated amounts of IL-1beta persists for hours after short-term exposures to elevated CO2
dimerized or endogenous caspase-8 (show CASP8 Proteins) can also directly cleave IL-1beta into its biologically active form, in the absence of canonical inflammasome components.
In this newborn mouse lung hypoxia-reoxygenation model, we found downregulation of genes of mediators of inflammation, an antiapoptotic gene expression pattern, and downregulation of DNA glycosylases. Sod1 (show SOD1 Proteins) and Il1b were significantly differentially expressed when comparing reoxygenation using 60% O2 with air.
Report direct role of pleural cells in the pathogenesis of bleomycin-induced pulmonary fibrosis via caspase-1 (show CASP1 Proteins)/IL-1beta pathway.
Icariin inhibits MMP1 (show MMP1 Proteins), MMP3 (show MMP3 Proteins) and MMP13 (show MMP13 Proteins) expression through MAPK (show MAPK1 Proteins) pathways in IL1betastimulated SW1353 chondrosarcoma cells
Sesamin showed anti-inflammatory effects in IL-1beta-stimulated chondrocytes by activating Nrf2 (show GABPA Proteins) signaling pathway.
In conclusion, the analyzed IL1A (show IL1A Proteins) -889 C>T, IL1B +3954 C>T, and IL6 (show IL6 Proteins) -174 G>C polymorphisms may be associated with the occurrence and development of human cytomegalovirus infection among studied patients.
Data showed that IL-1beta downregulates 15-PGDH (show HPGD Proteins) expression in pancreatic ductal adenocarcinoma (PDAC) cells, and that IL-1beta expression was inversely correlated with 15-PGDH (show HPGD Proteins) levels in frozen PDAC tissues resulting in poor prognosis.
Concentration of IL-1beta was significantly higher in patients with heart failure (HF) compared with non-HF and control groups. Results of the distribution of IL-1beta-31T/C genotypes and allele frequencies did not show any significant difference between the three groups. Serum levels of IL-1beta were found to be higher among TT genotype than TC and CC genotype.
the activation of Rho GTPases by the CNF1 toxin during E. coli-triggered bacteremia leads to a GR1(+)cell-mediated efficient bacterial clearing and improves host survival. Host alarm requires the Caspase-1 (show CASP1 Proteins)/IL-1beta signaling axis.
The level of miR (show MLXIP Proteins)-216b was significantly higher and Smad3 (show SMAD3 Proteins) expression was obviously lower in osteoarthritis cartilage and IL-1beta-induced chondrocytes than in normal tissues and cells.
C/EBPbeta (show CEBPB Proteins) overexpression or knockdown did not change the levels of IL-1beta-induced SOCS1 (show SOCS1 Proteins). SOCS1 (show SOCS1 Proteins) regulated the levels of C/EBPbeta (show CEBPB Proteins) mRNA by ubiquitination of C/EBPbeta (show CEBPB Proteins) as well as transcriptional regulation in human chondrocytes.
The obtained data demonstrate that the high level of production of IL-1b and IL-4 (show IL4 Proteins) in GN patients causes hypothyroidism resulting in the formation of nephrotic syndrome.
An association with IL-1beta-511 locus and IL-1beta-511-TLR4 (show TLR4 Proteins)-896 diplotype (CC-AA) and Type 2 Diabetes Mellitus is discussed.
This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.
local expression of IL-1beta and IL-8 (show IL8 Proteins) in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
IL1B regulates expression of IL1R1 (show IL1RN Proteins) and IL1RAP (show IL1RAP Proteins) and stimulates expression of PTGS1 (show PTGS1 Proteins) and PTGS2 (show PTGS2 Proteins) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (show PLIN1 Proteins)-implantation period of pregnancy in pigs.
the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.
The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 (show IL1RN Proteins) protein and IL1B and IL1R1 (show IL1RN Proteins) mRNA were detected.
For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor (show P2RX7 Proteins).
Role of TGF-beta1 (show TGFB1 Proteins) and TNF-alpha (show TNF Proteins) in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 (show IL6 Proteins) concentrations were greatest in the immediate pre-pubertal period.
Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.
Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF (show PGF Proteins)(2alpha) and PGE (show LIPF Proteins)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1 (show IL1A Proteins)-induced matrix degradation and loss of tissue material properties
dynamic compression stimulates cell proliferation and proteoglycan (show Vcan Proteins) synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 (show JUN Proteins) signalling pathways
These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha (show TNF Proteins) and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.
the low friction of articular cartilage can be modified by TGF-beta1 (show TGFB1 Proteins) and IL-1beta treatment and that the friction coefficient depends on multiple factors, including superficial zone protein localization and surface roughness
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 (show IL6 Proteins) in rabbit cornea cells.
IL-1beta and TNF-alpha (show TNF Proteins) expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha (show TNF Proteins).
IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.
The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.
Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1 (show TGFB1 Proteins), which delays the development of osteoarthritis.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2, and TGFbeta1 (show TGFB1 Proteins)
Increased PGE2 production led to reduction in 5-LO (show ALOX5 Proteins) products in LPS (show IRF6 Proteins)-treated equine whole blood via IL-1b.
Results suggested that chemokine (show CCL1 Proteins) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
IL-1beta-induced up-regulation of matrix metalloproteinase 13 (show MMP13 Proteins) mRNA was blocked by all concentrations of geldanamycin tested
This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
, IL-1 beta
, interleukin-1 beta
, preinterleukin 1 beta
, prointerleukin-1 beta
, Interleukin-1 beta
, precursor interleukin-1beta
, interleukin-1 beta proprotein
, interleukin 1 beta
, lymphocyte proliferation-potentiating factor