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anti-Rat (Rattus) NFKBIZ Antibodies:
anti-Mouse (Murine) NFKBIZ Antibodies:
anti-Human NFKBIZ Antibodies:
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Human Polyclonal NFKBIZ Primary Antibody for IHC (p) - ABIN5584488
Zhu, Li, Yang, Tian, Wang, Yuan, Dong, He, Wang, Li: Dynamics of the Transcriptome during Human Spermatogenesis: Predicting the Potential Key Genes Regulating Male Gametes Generation. in Scientific reports 2016
In cultured macrophages, LPS (show TLR4 Antibodies)-induced expression of monocyte chemoattractant protein (MCP)-1 (show CPT1B Antibodies) was suppressed by NaN3 through inhibition of STAT1 (show STAT1 Antibodies) and IkappaBzeta activities.
Data show that I-kappa-B-zeta (IkappaBzeta) regulates macrophage interleukin-10 (show IL10 Antibodies) (IL_10) expression by directly activated the Il-10 (show IL10 Antibodies) promoter.
A possible important role of Nfkbiz in modulating the progression of inflammatory diseases in which IFN-gamma (show IFNG Antibodies) and IL-1 (show IL1A Antibodies) are abundant.
Nfkbiz-/- keratinocytes were hypoproliferative. In skin from Nfkbiz-/- mice, the expression of the keratinocyte differentiation markers K10 (show KRT10 Antibodies) and filaggrin (show FLG Antibodies) were reduced, although that of K14 (show KRT14 Antibodies) was unchanged.
These data reveal a previously unappreciated role for IkappaB-zeta in IFN-gamma (show IFNG Antibodies) production in T cells and the immunoregulatory function of T regulatory cells.
The pyrimidine-rich IkappaBzeta-responsive site plays an essential role in productive interaction of IkappaBzeta with the p50 (show LSP1 Antibodies)-DNA complex.
IkappaB-zeta regulates TLR-mediated CSR (show SCARA3 Antibodies) by inducing AID
The IkappaB-zeta-Akirin2 (show AKIRIN2 Antibodies)-BAF60 complex physically links the NF-kappaB (show NFKB1 Antibodies) and SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complexes in innate immune cell activation.
The IkappaB-zeta-deficient B cells exhibited impaired proliferation and enhanced up-regulation of CD86 (show CD86 Antibodies) following stimulation of TLR9 (show TLR9 Antibodies), but not the BCR (show BCR Antibodies), indicating critical roles for IkappaB-zeta in TLR signaling in B cells.
IkappaBzeta-deficient mice showed significantly impaired CCL2 (show CCL2 Antibodies) secretion.
a specific IL-17A (show IL17A Antibodies)-induced gene, NFKBIZ, which encodes IkappaB-zeta, a transcriptional regulator for NF-kappaB (show NFKB1 Antibodies), was demonstrated to have a significant role for IL-17A (show IL17A Antibodies)-induced gene expression.
In cultured macrophages, LPS (show IRF6 Antibodies)-induced expression of monocyte chemoattractant protein (MCP)-1 (show CCL2 Antibodies) was suppressed by NaN3 through inhibition of STAT1 (show STAT1 Antibodies) and IkappaBzeta activities.
IkappaB-zeta regulates human monocyte pro-inflammatory responses induced by Streptococcus pneumoniae.
TNF-alpha (show TNF Antibodies)- and IL-17A (show IL17A Antibodies) mediate synergistic induction of DEFB4 (show DEFB104A Antibodies) gene expression in human keratinocytes through IkappaBzeta
We propose a previously unappreciated role of IkappaBzeta in the inflammatory micromilieu as well as progression in glioma
These results indicate that the LPS (show IRF6 Antibodies)/IL-1beta (show IL1B Antibodies)-MyD88 (show MYD88 Antibodies) axis plays a crucial role for stabilization of IkappaB-zeta mRNA.
Interferon-gamma (IFN-gamma (show IFNG Antibodies)) interferes with the IL-1 (show IL1A Antibodies)/IKB-zeta axis in beta-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFN-gamma (show IFNG Antibodies) and IL-22 (show IL22 Antibodies).
NFKBIZ gene knockdown in bronchial epithelial cells suppresses the release of IL-1b (show IL1B Antibodies)-induced IL-6 (show IL6 Antibodies) and GMCSF (show CSF2 Antibodies).
IkappaBzeta functions as an important regulator of IFN-gamma (show IFNG Antibodies) in human NK cells
NF-kappaB (show NFKB1 Antibodies)-binding cofactor inhibitor of NF-kappaB (show NFKB1 Antibodies)-zeta (IkappaB-zeta) is constitutively expressed in HTLV-I-infected T cell lines and ATL cells, and Tax (show CNTN2 Antibodies) transactivates the IkappaB-zeta gene, mainly through NF-kappaB (show NFKB1 Antibodies).
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.
, NF-kappa-B inhibitor zeta
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
, molecule associated with ankyrin repeats induced by lipopolysaccharide
, NF-kappa-B inhibitor zeta-like
, IL-1 inducible nuclear ankyrin-repeat protein
, molecule possessing ankyrin repeats induced by lipopolysaccharide
, molecule possessing ankyrin-repeats induced by lipopolysaccharide
, Ikappa B-zeta variant 3
, molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL), homolog of mouse