NFKBIZ antibody

Catalog No. ABIN7116967

This Rabbit Polyclonal antibody specifically detects NFKBIZ in WB, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NFKBIZ antibody (ABIN7116967)

Target: NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFKBIZ antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-NFKBIZ Antibody

Purpose: NFKBIZ antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for NFKBIZ

Target: NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))

Alternative Name: NFKBIZ

Background:

Synonyms: NF-kappa-B inhibitor zeta|I-kappa-B-zeta (IkB-zeta, IkappaBzeta)|IL-1 inducible nuclear ankyrin-repeat protein (INAP)|Molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL)|NFKBIZ|IKBZ|INAP|MAIL

Background: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis(By similarity).

Molecular Weight: 64 kDa

Gene ID: 64332

UniProt: Q9BYH8

Pathways: NF-kappaB Signaling