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anti-Human SQSTM1 Antibodies:
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Human Monoclonal SQSTM1 Primary Antibody for IF, ELISA - ABIN563860
Jung, Chung, Won Kim, Kim, Komatsu, Tanaka, Nguyen, Kang, Yoon, Kim, Jeong, Han, Lee, Kim, Shin, Lee: Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. in Cell metabolism 2008
Show all 88 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for ICC, IF - ABIN4343147
Pyo, Yoo, Ahn, Nah, Hong, Kam, Jung, Jung: Overexpression of Atg5 in mice activates autophagy and extends lifespan. in Nature communications 2013
Show all 36 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for IF, IHC (p) - ABIN388979
Seibenhener, Babu, Geetha, Wong, Krishna, Wooten: Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. in Molecular and cellular biology 2004
Show all 22 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for WB - ABIN1881829
Visconti, Langston, Alonso, Goodman, Selby, Fraser, Ralston: Mutations of SQSTM1 are associated with severity and clinical outcome in paget disease of bone. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010
Show all 5 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for DB - ABIN1881831
Ding, Ni, Li, Liao, Chen, Stolz, Dorn, Yin: Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. in The Journal of biological chemistry 2010
Show all 5 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for DB - ABIN1881830
Jain, Lamark, Sjøttem, Larsen, Awuh, Øvervatn, McMahon, Hayes, Johansen: p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. in The Journal of biological chemistry 2010
Show all 5 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for IF (p), IHC (p) - ABIN682153
Cui, Luo, Li, Li, Wang: Changes of intracellular Ca2+ in quercetin-induced autophagy progression. in Acta biochimica et biophysica Sinica 2015
Show all 4 Pubmed References
Human Monoclonal SQSTM1 Primary Antibody for ELISA, WB - ABIN522359
Kirkin, Lamark, Sou, Bjørkøy, Nunn, Bruun, Shvets, McEwan, Clausen, Wild, Bilusic, Theurillat, Øvervatn, Ishii, Elazar, Komatsu, Dikic, Johansen: A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. in Molecular cell 2009
Show all 4 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for ICC, IF - ABIN4343150
Gispert, Brehm, Weil, Seidel, Rüb, Kern, Walter, Roeper, Auburger: Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression. in Human molecular genetics 2015
Show all 3 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for IHC, IHC (p) - ABIN4343148
Moreau, Fleming, Imarisio, Lopez Ramirez, Mercer, Jimenez-Sanchez, Bento, Puri, Zavodszky, Siddiqi, Lavau, Betton, OKane, Wechsler, Rubinsztein: PICALM modulates autophagy activity and tau accumulation. in Nature communications 2014
Show all 2 Pubmed References
p62 deficiency in stromal fibroblasts promotes resistance to glutamine deprivation by the direct control of ATF4 stability through its p62-mediated polyubiquitination.
AGG is also found to trigger ubiquitination of PUMA which in turn interacted with p62 for prompting mitophagy suggesting that AGG turns on PUMA-mediated mitophagy in U87MG cells in both p62-dependent as well as in p62-independent manner
The results suggest that p62 may be an effective predictor of prognosis and a potential target for therapy in osteosarcoma.
The model reveals a compensatory autophagic pathway, mediated by a SQSTM1/p62-dependent clearance of accumulated polyubiquitinated proteins. In addition to mediating the sequestration of ubiquitinated cargos into phagophores, the precursors to autophagosomes, SQSTM1 is also important for polyubiquitinated aggregate formation upon proteasomal inhibition.
ESI (show PI3 Antibodies) induces protective autophagy of lung cancer cells through Nrf2 (show GABPA Antibodies)-p62 (show GTF2H1 Antibodies)-keap1 (show KEAP1 Antibodies) feedback loop
IFN-gamma induces activated but insufficient autophagy and thus contributes to a degree to p62-dependent apoptosis of nasal epithelial cells in chronic rhinosinusitis with nasal polyps.
The underling mechanism of autophagy/p62 (show GTF2H1 Antibodies)/Nrf2 (show GABPA Antibodies) pathway discovered may provide a new direction for drug development.
Study show the proteasome autophagy mechanism is mediated by the p62/SQSTM1 adapter and requires its ubiquitin-associated domain. Independently, p62 (show GTF2H1 Antibodies) serves also as a shuttling protein for ubiquitinated substrates, using its PB1 (show SMR3A Antibodies) domain. This places p62 (show GTF2H1 Antibodies) in a pivotal position where under certain conditions it binds to the proteasome as a protease, whereas in other conditions it recognizes the proteasome as a prey.
The study describes a previously uncharacterized cellular response induced by heme: the formation of p62/SQSTM1 aggregates containing ubiquitinated proteins in structures known as aggresome-like induced structures (ALIS). This action is part of a response driven by the transcription factor NRF2 (show GABPA Antibodies) to the excessive generation of reactive oxygen species induced by heme.
The data identify an intricate mechanism of hepatitis C virus-dependent inhibition of Nrf2 (show GABPA Antibodies)/ antioxidant response elements-mediated gene expression which counteracts serine 349-phosphorylated p62 (show GTF2H1 Antibodies)-induced activation of Nrf2 (show GABPA Antibodies).
p62 serves to prevent endoplasmic reticulum stress in mouse hypothalamus by maintaining protein folding capacity
The p62 (show GTF2H1 Antibodies)-keap1 (show KEAP1 Antibodies)-Nrf2 (show NFE2L2 Antibodies) antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
Endogenous p62 undergoes E2-dependent ubiquitylation during upregulation of Ubiquitin (Ub) homeostasis, a condition termed as Ub(+) stress, that is intrinsic to Ub overexpression, heat shock or prolonged proteasomal inhibition by bortezomib, a chemotherapeutic drug.
analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 (show MAP1LC3A Antibodies) using a combination of fluorescence microscopy-based biophysical approaches in living cells
ENC1 (show ENC1 Antibodies) interacts with the phosphorylated p62 (show GTF2H1 Antibodies) to impair autophagic degradation of mutant huntingtin (show HTT Antibodies) protein aggregates.
this study proved that SYVN1 (show SYVN1 Antibodies) enhances SERPINA1 (show SERPINA1 Antibodies)(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1 (show SERPINA1 Antibodies)(E342K)/ATZ cytotoxicity.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 and Lc3 (show MAP1LC3A Antibodies)-II/Map1lc3 (show MAP1LC3B Antibodies) in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (show GTF2H1 Antibodies) and down-regulates Lc3 (show MAP1LC3A Antibodies)-II in neonatal liver. (p62/Sqstm1 = sequestosome 1; Lc3 (show MAP1LC3A Antibodies)-II/Map1lc3 (show MAP1LC3B Antibodies) = microtubule-associated protein (show SPAG5 Antibodies) 1-light chain 3)
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
SQSTM1 dynamically associates with DNA damage foci (DDF) and regulates DNA repair.
Thyroid hormone (show PTH Antibodies) promotes selective autophagy via induction of DAPK2 (show DAPK2 Antibodies)-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
, sqstm1 protein
, EBI3-associated protein of 60 kDa
, EBI3-associated protein p60
, oxidative stress induced like
, phosphotyrosine independent ligand for the Lck SH2 domain p62
, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
, ubiquitin-binding protein p62
, oxidative stress induced
, PKC-zeta-interacting protein
, protein kinase C-zeta-interacting protein