Browse our anti-SQSTM1 (SQSTM1) Antibodies

Full name:: anti-Sequestosome 1 Antibodies (SQSTM1)

On www.antibodies-online.com are 373 Sequestosome 1 (SQSTM1) Antibodies from 26 different suppliers available. Additionally we are shipping SQSTM1 Kits (13) and SQSTM1 Proteins (12) and many more products for this protein. A total of 412 SQSTM1 products are currently listed.

Synonyms:: A170, MGC79491, OSF-6, Osi, OSIL, p60, p62, p62B, PDB3, sb:cb621, sqstm1, STAP, zgc:85784, ZIP, ZIP3

list all antibodies	Gene Name	GeneID	UniProt
	SQSTM1	8878	Q13501
	SQSTM1	18412	Q64337
	SQSTM1	113894	O08623
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Most Popular Reactivities for anti-SQSTM1 (SQSTM1) Antibodies

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anti-Human SQSTM1 Antibodies:

anti-Mouse (Murine) SQSTM1 Antibodies:

anti-Rat (Rattus) SQSTM1 Antibodies:

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Relevant Pathways for anti-SQSTM1 Antibodies

Autophagy

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Top referenced anti-SQSTM1 Antibodies

Human Monoclonal SQSTM1 Primary Antibody for IF, ELISA - ABIN563860 : Jung, Chung, Won Kim, Kim, Komatsu, Tanaka, Nguyen, Kang, Yoon, Kim, Jeong, Han, Lee, Kim, Shin, Lee: Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. in Cell metabolism 2008 (PubMed)
Show all 88 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for ICC, IF - ABIN4343147 : Pyo, Yoo, Ahn, Nah, Hong, Kam, Jung, Jung: Overexpression of Atg5 in mice activates autophagy and extends lifespan. in Nature communications 2013 (PubMed)
Show all 36 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for IF, IHC (p) - ABIN388979 : Seibenhener, Babu, Geetha, Wong, Krishna, Wooten: Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. in Molecular and cellular biology 2004 (PubMed)
Show all 25 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for DB - ABIN1881830 : Visconti, Langston, Alonso, Goodman, Selby, Fraser, Ralston: Mutations of SQSTM1 are associated with severity and clinical outcome in paget disease of bone. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 (PubMed)
Show all 5 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for WB - ABIN1881829 : Ding, Ni, Li, Liao, Chen, Stolz, Dorn, Yin: Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. in The Journal of biological chemistry 2010 (PubMed)
Show all 5 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for DB - ABIN1881831 : Jain, Lamark, Sjøttem, Larsen, Awuh, Øvervatn, McMahon, Hayes, Johansen: p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. in The Journal of biological chemistry 2010 (PubMed)
Show all 5 Pubmed References
Human Polyclonal SQSTM1 Primary Antibody for ELISA, ICC - ABIN6263985 : Wu, Huang, Jiao, Ding, Zhang, Chen, Wang, Li, Huo: Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells. in Oncotarget 2017 (PubMed)
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Human Polyclonal SQSTM1 Primary Antibody for IHC (fro), IHC (p) - ABIN3043937 : Li, Jen, Wu, Lee, Fang, Quigley, Lee, Wang, Zhou, Vergnes, Chen, Li, Reue, Ann, Hsiai: Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis. in Antioxidants & redox signaling 2016 (PubMed)
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Human Polyclonal SQSTM1 Primary Antibody for IF (p), IHC (p) - ABIN682153 : Cui, Luo, Li, Li, Wang: Changes of intracellular Ca2+ in quercetin-induced autophagy progression. in Acta biochimica et biophysica Sinica 2015 (PubMed)
Show all 4 Pubmed References
Human Monoclonal SQSTM1 Primary Antibody for ELISA, WB - ABIN522359 : Kirkin, Lamark, Sou, Bjørkøy, Nunn, Bruun, Shvets, McEwan, Clausen, Wild, Bilusic, Theurillat, Øvervatn, Ishii, Elazar, Komatsu, Dikic, Johansen: A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. in Molecular cell 2009 (PubMed)
Show all 4 Pubmed References

More Antibodies against SQSTM1 Interaction Partners

Human Sequestosome 1 (SQSTM1) interaction partners

p62 and ubiquitinated proteins spontaneously coalesce into larger clusters. Efficient cluster formation requires substrates modified with at least two ubiquitin chains longer than three moieties and is based on p62 filaments cross-linked by the substrates.
27-OH induced autophagy is dependent on the relation between nuclear factor erythroid 2 p45-related factor 2 (Nrf2)-dependent antioxidant response and p62.
our results showed that high CD44 (show CD44 Antibodies) led to p62 (show GTF2H1 Antibodies)-associated NRF2 (show GABPA Antibodies) activation in CD44 (show CD44 Antibodies)(high) breast CSC-like cells. NRF2 (show GABPA Antibodies) activation contributed to the aggressive phenotype, tumor growth, and anticancer drug resistance of CD44 (show CD44 Antibodies)(high) CSCs
results suggested that p62 plays a protective role in adipogenesis of human adipose-derived stromal cells through regulating mitophagy.
The results of the present study demonstrated that p62 may aggravate LPSinduced acute kidney injury in mice by promoting apoptosis in renal tubular epithelial cells.
Study supports HuR's role as an upstream regulator of p62 expression in ARPE-19 cells, helps to understand better the early events in response to a proautophagy stimulus.
Therefore in this review we discuss the role of p62 in autophagy, apoptosis and cancer through its different domains and outline the importance of modulating cellular levels of p62 in cancer therapeutics.
Both the metastatic and recurrent tumor tissues expressed less p62 than the patient-matched primary tumor. A significant inverse correlation has been found between p62 expression and both the disease-free survival and overall survival.
p62 deficiency in stromal fibroblasts promotes resistance to glutamine deprivation by the direct control of ATF4 stability through its p62-mediated polyubiquitination.
AGG is also found to trigger ubiquitination of PUMA which in turn interacted with p62 for prompting mitophagy suggesting that AGG turns on PUMA-mediated mitophagy in U87MG cells in both p62-dependent as well as in p62-independent manner

Mouse (Murine) Sequestosome 1 (SQSTM1) interaction partners

These results suggest that overexpression of SQSTM1 in SOD1 (show SOD1 Antibodies) (H46R) mice accelerates disease onset by compromising the protein degradation pathways.
these results suggested that trehalose can function as a novel activator of the p62 (show GTF2H1 Antibodies)-Keap1 (show KEAP1 Antibodies)/Nrf2 (show NFE2L2 Antibodies) pathway, in addition to inducing autophagy. Therefore, trehalose may be useful to treat many chronic diseases involving oxidative stress and dysfunction of autophagy.
The studies findings imply that p62 signaling plays a crucial role in suppressing inflammatory cytokine production by globular adiponectin in macrophages.
Data, including data from studies in transgenic and knockout mice, suggest that p62/Sqstm1 is not required for normal pancreatic islet organization and beta-cell secretion of insulin (show INS Antibodies).
Deletion of both p62/Sqstm1 and Nrf2 (show NFE2L2 Antibodies) genes spontaneously leads to the development of NASH (show SAMSN1 Antibodies).
p62 serves to prevent endoplasmic reticulum stress in mouse hypothalamus by maintaining protein folding capacity
The p62 (show GTF2H1 Antibodies)-keap1 (show KEAP1 Antibodies)-Nrf2 (show NFE2L2 Antibodies) antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
Endogenous p62 undergoes E2-dependent ubiquitylation during upregulation of Ubiquitin (Ub) homeostasis, a condition termed as Ub(+) stress, that is intrinsic to Ub overexpression, heat shock or prolonged proteasomal inhibition by bortezomib, a chemotherapeutic drug.
analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 (show MAP1LC3A Antibodies) using a combination of fluorescence microscopy-based biophysical approaches in living cells
ENC1 (show ENC1 Antibodies) interacts with the phosphorylated p62 (show GTF2H1 Antibodies) to impair autophagic degradation of mutant huntingtin (show HTT Antibodies) protein aggregates.

Zebrafish Sequestosome 1 (SQSTM1) interaction partners

Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.

SQSTM1 Antigen Profile

Antigen Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with SQSTM1

sequestosome 1 (SQSTM1) antibody
sequestosome 1 (sqstm1) antibody
sequestosome 1 (Sqstm1) antibody
sequestosome 1 L homeolog (sqstm1.L) antibody

A170 antibody
MGC79491 antibody
OSF-6 antibody
Osi antibody
OSIL antibody
p60 antibody
p62 antibody
p62B antibody
PDB3 antibody
sb:cb621 antibody
sqstm1 antibody
STAP antibody
zgc:85784 antibody
ZIP antibody
ZIP3 antibody

Protein level used designations for anti-Sequestosome 1 (SQSTM1) Antibodies

sequestosome 1 , sequestosome-1 , sequestosome-1-like , sqstm1 protein , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , ubiquitin-binding protein p62 , STONE14 , oxidative stress induced , PKC-zeta-interacting protein , protein kinase C-zeta-interacting protein

GENE ID	SPECIES
462333	Pan troglodytes
705481	Macaca mulatta
770805	Gallus gallus
100135450	Ovis aries
100342157	Oryctolagus cuniculus
100385650	Callithrix jacchus
493277	Xenopus (Silurana) tropicalis
100067231	Equus caballus
8878	Homo sapiens
18412	Mus musculus
113894	Rattus norvegicus
406452	Danio rerio
379610	Xenopus laevis
338045	Bos taurus
481459	Canis lupus familiaris
100172461	Pongo abelii

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Show all anti-Sequestosome 1 (SQSTM1) Antibodies with Pubmed References