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SQSTM1 antibody (AA 1-440)

SQSTM1 Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 2C11 unconjugated
Catalog No. ABIN563860
  • Target See all SQSTM1 Antibodies
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Binding Specificity
    • 19
    • 17
    • 15
    • 13
    • 11
    • 11
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-440
    Reactivity
    • 171
    • 64
    • 61
    • 18
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 146
    • 23
    • 1
    • 1
    Mouse
    Clonality
    • 145
    • 26
    Monoclonal
    Conjugate
    • 77
    • 13
    • 12
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SQSTM1 antibody is un-conjugated
    Application
    • 121
    • 57
    • 49
    • 40
    • 25
    • 23
    • 18
    • 16
    • 14
    • 13
    • 10
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Purpose
    Mouse monoclonal antibody raised against a full length recombinant SQSTM1.
    Sequence
    MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN MVHPNVICDG CNGPVVGTRY KCSVCPDYDL CSVCEGKGLH RGHTKLAFPS PFGHLSEGFS HSRWLRKVKH GHFGWPGWEM GPPGNWSPRP PRAGEARPGP TAESASGPSE DPSVNFLKNV GESVAAALSP LGIEVDIDVE HGGKRSRLTP VSPESSSTEE KSSSQPSSCC SDPSKPGGNV EGATQSLAEQ MRKIALESEG RPEEQMESDN CSGGDDDWTH LSSKEVDPST GELQSLQMPE SEGPSSLDPS QEGPTGLKEA ALYPHLPPEA DPRLIESLSQ MLSMGFSDEG GWLTRLLQTK NYDIGAALDT IQYSKHPPPL
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Antibody Reactive Against Recombinant Protein.
    Immunogen
    SQSTM1 (AAH03139.1, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Clone
    2C11
    Isotype
    IgG2a
    Top Product
    Discover our top product SQSTM1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    In 1x PBS, pH 7.4
    Handling Advice
    Aliquot to avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Korwitz, Merkwirth, Richter-Dennerlein, Tröder, Sprenger, Quirós, López-Otín, Rugarli, Langer: "Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria." in: The Journal of cell biology, Vol. 212, Issue 2, pp. 157-66, (2016) (PubMed).

    Sydow, Hochgräfe, Könen, Cadinu, Matenia, Petrova, Joseph, Dennissen, Mandelkow: "Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD." in: Acta neuropathologica communications, Vol. 4, pp. 17, (2016) (PubMed).

    Winner, Beard, Hassiotis, Lau, Luck, Hopwood, Hemsley: "A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome." in: Human gene therapy, Vol. 27, Issue 5, pp. 363-75, (2016) (PubMed).

    He, Hamm, Reddy, Sams, Peliciari-Garcia, McGinnis, Bailey, Chow, Rowe, Chatham, Young: "Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism." in: American journal of physiology. Heart and circulatory physiology, Vol. 310, Issue 11, pp. H1520-32, (2016) (PubMed).

    Jin, Hong, Park, Chang, Hong, Park, Lee: "Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors." in: Scientific reports, Vol. 6, pp. 28945, (2016) (PubMed).

    Aydinlik, Erkisa, Cevatemre, Sarimahmut, Dere, Ari, Ulukaya: "Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line." in: Biochimica et biophysica acta, Vol. 1861, Issue 2, pp. 49-57, (2016) (PubMed).

    Redmann, Benavides, Berryhill, Wani, Ouyang, Johnson, Ravi, Barnes, Darley-Usmar, Zhang: "Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons." in: Redox biology, Vol. 11, pp. 73-81, (2016) (PubMed).

    Garofalo, Iovine, Kuryk, Capasso, Hirvinen, Vitale, Yliperttula, Bevilacqua, Cerullo: "Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity." in: Molecular cancer therapeutics, Vol. 15, Issue 4, pp. 651-60, (2016) (PubMed).

    Morgan, Thorburn: "Measuring Autophagy in the Context of Cancer." in: Advances in experimental medicine and biology, Vol. 899, pp. 121-43, (2016) (PubMed).

    Wilson, Nikolic, Kentish, Shalini, Hatzinikolas, Page, Dorstyn, Kumar: "Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice." in: Cell death discovery, Vol. 2, pp. 16009, (2016) (PubMed).

    Conlon, Thomas, Fedotova, Hernandez-Ono, Di Paolo, Chan, Ruggles, Gibeley, Liu, Ginsberg: "Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis." in: The Journal of clinical investigation, Vol. 126, Issue 10, pp. 3852-3867, (2016) (PubMed).

    de Luxán-Delgado, Caballero, Potes, Rubio-González, Rodríguez, Gutiérrez-Rodríguez, Solano, Coto-Montes: "Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation." in: Journal of pineal research, Vol. 56, Issue 2, pp. 126-33, (2015) (PubMed).

    Niso-Santano, Malik, Pietrocola, Bravo-San Pedro, Mariño, Cianfanelli, Ben-Younès, Troncoso, Markaki, Sica, Izzo, Chaba, Bauvy, Dupont, Kepp, Rockenfeller, Wolinski, Madeo, Lavandero, Codogno, Harper et al.: "Unsaturated fatty acids induce non-canonical autophagy. ..." in: The EMBO journal, (2015) (PubMed).

    Kucukgul, Ozler, Inci, Karakas, Irmak, Gozuacik, Taralp, Koc: "3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells." in: Biotechnology and bioengineering, Vol. 112, Issue 4, pp. 811-21, (2015) (PubMed).

    Li, Shi, He, Hu, Wang, Zhang, Chan, Chen: "Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells." in: PLoS ONE, Vol. 10, Issue 3, pp. e0122753, (2015) (PubMed).

    Porta, Kwong, Trojanowski, Lee: "Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases." in: Journal of neuropathology and experimental neurology, Vol. 74, Issue 4, pp. 380-7, (2015) (PubMed).

    Yang, Peng, Ni, Li, Shi, Ding, Fan: "Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth." in: PLoS ONE, Vol. 10, Issue 6, pp. e0130953, (2015) (PubMed).

    Dou, Xu, Donahue, Shimi, Pan, Zhu, Ivanov, Capell, Drake, Shah, Catanzaro, Ricketts, Lamark, Adam, Marmorstein, Zong, Johansen, Goldman, Adams, Berger: "Autophagy mediates degradation of nuclear lamina." in: Nature, Vol. 527, Issue 7576, pp. 105-9, (2015) (PubMed).

    Cinque, Forrester, Bartolomeo, Svelto, Venditti, Montefusco, Polishchuk, Nusco, Rossi, Medina, Polishchuk, De Matteis, Settembre: "FGF signalling regulates bone growth through autophagy." in: Nature, Vol. 528, Issue 7581, pp. 272-5, (2015) (PubMed).

    Tung, Wang, Hsu, Hu, Her, Huang, Liao: "Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation." in: Molecular neurobiology, Vol. 49, Issue 1, pp. 10-27, (2014) (PubMed).

  • Target
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Alternative Name
    SQSTM1 (SQSTM1 Products)
    Synonyms
    SQSTM1 antibody, sqstm1 antibody, MGC79491 antibody, A170 antibody, OSIL antibody, PDB3 antibody, ZIP3 antibody, p60 antibody, p62 antibody, p62B antibody, OSF-6 antibody, Osi antibody, STAP antibody, ZIP antibody, sb:cb621 antibody, zgc:85784 antibody, sequestosome 1 antibody, sequestosome 1 L homeolog antibody, SQSTM1 antibody, sqstm1 antibody, Sqstm1 antibody, sqstm1.L antibody
    Background
    Full Gene Name: sequestosome 1
    Synonyms: A170,OSIL,PDB3,ZIP3,p60,p62,p62B
    Gene ID
    8878
    Pathways
    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy
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