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anti-Human Tumor Necrosis Factor Antibodies:
anti-Rat (Rattus) Tumor Necrosis Factor Antibodies:
anti-Mouse (Murine) Tumor Necrosis Factor Antibodies:
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Mouse (Murine) Polyclonal Tumor Necrosis Factor Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900489
Ramkhelawon, Hennessy, Ménager, Ray, Sheedy, Hutchison, Wanschel, Oldebeken, Geoffrion, Spiro, Miller, McPherson, Rayner, Moore: Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. in Nature medicine 2014
Show all 53 Pubmed References
Rat (Rattus) Polyclonal Tumor Necrosis Factor Primary Antibody for WB - ABIN3042522
Zhang, Liu, Goldstein, Li, Ge, He, Fei, Wang, Ruiz: Role of the JAK/STAT signaling pathway in the pathogenesis of acute myocardial infarction in rats and its effect on NF-?B expression. in Molecular medicine reports 2013
Show all 38 Pubmed References
Mouse (Murine) Polyclonal Tumor Necrosis Factor Primary Antibody for WB - ABIN3043313
Liu, Shan, Dong, Liu, Ma, Liu: Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. in World journal of gastroenterology 2013
Show all 38 Pubmed References
Mouse (Murine) Polyclonal Tumor Necrosis Factor Primary Antibody for ELISA, IHC (p) - ABIN3042817
Qin, Ma, Yang, Hu, Zhou, Fu, Tian, Liu, Xu, Shen: A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes. in Natural products and bioprospecting 2015
Show all 30 Pubmed References
Human Monoclonal Tumor Necrosis Factor Primary Antibody for - ABIN1383955
Hervé, Racadot, Wijdenes, Flesch, Tiberghien, Bordigoni, Holler, Powles, Bourdeau, Wilmer: Monoclonal anti TNF alpha antibody in the treatment of acute GvHD refractory both to corticosteroids and anti IL-2 R antibody. in Bone marrow transplantation 1991
Show all 15 Pubmed References
Human Polyclonal Tumor Necrosis Factor Primary Antibody for ICC, IF - ABIN446837
Kwon, Jung, Hwang, Choi: Evaluation of Bronchiolar and Alveolar Cell Injuries Induced by Short- and Long-term Exposure to Sidestream Smoke. in Korean journal of pathology 2012
Show all 13 Pubmed References
Human Polyclonal Tumor Necrosis Factor Primary Antibody for IF (p), IHC (p) - ABIN677318
Morishita, Oku, Horie, Tonari, Kida, Okubo, Sugiyama, Takai, Hara, Ikeda: Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-?B activation. in PLoS ONE 2014
Show all 12 Pubmed References
Human Polyclonal Tumor Necrosis Factor Primary Antibody for IHC (p), IHC - ABIN153474
Roth, Städler, Lemann, Hösli, Simon, Simon: Distinct eosinophil cytokine expression patterns in skin diseases - the possible existence of functionally different eosinophil subpopulations. in Allergy 2011
Show all 9 Pubmed References
Chicken Polyclonal Tumor Necrosis Factor Primary Antibody for IHC, ELISA - ABIN1582141
Choi, Lim, Hwang, Lee, Cho, Kim: Anti-ischemic and anti-inflammatory activity of (S)-cis-verbenol. in Free radical research 2010
Show all 9 Pubmed References
Human Monoclonal Tumor Necrosis Factor Primary Antibody for FACS - ABIN4898910
Glässner, Eisenhardt, Krämer, Körner, Coenen, Sauerbruch, Spengler, Nattermann: NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner. in Laboratory investigation; a journal of technical methods and pathology 2012
Show all 8 Pubmed References
Inter-group comparisons of cytokine levels demonstrated no significant differences in TNF-alpha, IL-6 (show IL6 Antibodies) and IL-8 (show IL8 Antibodies) cytokines levels. IL-10 (show IL10 Antibodies) level showed a moderately significant increase in the modified St. Thomas' group compared to the del Nido group after surgery (2.94+/-0.9 vs. 2.46+/-0.61 log10 pg/mL, respectively; p=0.039).
TNFalpha induced upregulation of MUC4 (show MUC4 Antibodies) that reduced trastuzumab binding to its epitope and impaired ADCC. Administration of TNFalpha-blocking antibodies downregulated MUC4 (show MUC4 Antibodies) and sensitized de novo trastuzumab-resistant breast cancer cells and tumors to trastuzumab.
our findings demonstrated that circulating TNF-alpha was significantly higher in OSAS patients than in controls, and this difference became more pronounced with the more severe grades of OSAS, indicating that TNF-alpha might be a promising circulating biomarker for the development of OSAS.
our findings show that imperatorin inhibits TNF-alpha-induced ROS (show ROS1 Antibodies) generation. Taken together, imperatorin can blunt inflammation by inhibiting the ROS (show ROS1 Antibodies)-mediated activation of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) pathway
TNF-alpha inhibitors decrease histone (H)3 and H4 acetylation in the RORgammat gene promotor region by decreasing the recruitment of the acetyltransferases p300 (show EP300 Antibodies), CBP (show CREBBP Antibodies) and PCAF (show KAT2B Antibodies) in Th17 cells, from rheumatoid arthritis patients.
Homozygous genotype TNF-a (-308A/G) was associated with the relative risk of Chronic Respiratory Diseases in foundry workers.
These results indicate that not H1 but M3 receptor-induced activation of p38 MAPK (show MAPK14 Antibodies) might contribute to the maintenance of epithelial barrier function through down-regulation of TNF-alpha signalling and activation of EGFR (show EGFR Antibodies).
Determined a novel role of TNF-alpha in inducing Bmal1 (show ARNTL Antibodies) via dual calcium dependent pathways; Roralpha was up-regulated in the presence of Ca(2 (show CA2 Antibodies)+) influx and Rev-erbalpha (show NR1D1 Antibodies) was down-regulated in the absence of that.
Inhibiting tumor necrosis factor-alpha diminishes desmoplasia and inflammation to overcome chemoresistance in pancreatic ductal adenocarcinoma cells.
Calyptranthes grandifolia O.Berg (Myrtaceae) ethanolic extract inhibits TNF-alpha gene expression and cytokine release in vitro
Inhibition of signaling stimulated by both TNF and IL1beta (show IL1B Antibodies) synergizes with NF-kappaB (show NFKB1 Antibodies) inhibition in eliminating leukemic stem cells.
Results show that interleukin 6 (IL6 (show IL6 Antibodies)) promotes oval cell proliferation and liver regeneration, while tumor necrosis factor alpha (TNFalpha) and TNF receptor-1(TNFR1 (show TNFRSF1A Antibodies)) do not affect this process.
This study adds to the evidence that both peripheral and brain region-specific increases in tumor necrosis factor alpha lead to both sickness and depression- and anxiety disorder-relevant behavior and do so via different pathways.
Lactosylceramide-Induced Phosphorylation Signaling to Group IVA Phospholipase A2 (show YWHAZ Antibodies) via Reactive Oxygen Species in Tumor Necrosis Factor-alpha-Treated Cells.
The current study demonstrated that honey can stimulate or suppress the mRNA expression of some pro-inflammatory cytokines in mice brains. Furthermore, honey suppresses the TNF-alpha mRNA expression in the presence of T. gondii infection but it stimulates the IL-1beta (show IL1B Antibodies) and IL-6 (show IL6 Antibodies) mRNA expression. Treatment of the mice with honey reduces parasite multiplication in the brain.
aerobic interval training enhanced the anti-inflammatory indices IL-10 (show IL10 Antibodies)/TNF-alpha ratio and IL-15 (show IL15 Antibodies) expression in skeletal muscle in tumor-bearing mice.
findings suggest that activation of Tnf-Aicda (show AICDA Antibodies) axis and co-inhibitory signals to T cells in coordination with Th1 (show HAND1 Antibodies)-type immunity has critical roles in the immune response against Hepatitis B virus infection
Taken together, we speculate that DT-13 inhibits endothelium vascular inflammation through regulating nitric oxide production and the expression of ROS (show ROS1 Antibodies), TNFR (show TNFRSF1A Antibodies), IL-8 (show IL8 Antibodies), MCP-1 (show CPT1B Antibodies), which are associated with inflammation.
TNF signalling is required for the expansion and differentiation of pathogenic IFNgamma+CD4 (show CD4 Antibodies)+ T cells that promote the irreversible loss of bone marrow function.
Data suggest that luteolytic factors (such as TNFa, interferon gamma (show IFNG Antibodies), and PGF2a) control expression of MMP1 (show MMP1 Antibodies), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.
These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (show TNFRSF1B Antibodies) mRNA transcription in the embryo.
There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.
SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.
Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (show PTGES Antibodies)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (show FAS Antibodies) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
TNF-alpha up-regulates NaV1.7 (show SCN9A Antibodies) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha
These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (show NOS2 Antibodies) pathways in the regulation of this pathological condition.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
these findings provide the direct evidence that ADAM17 (show ADAM17 Antibodies) cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (show PDCD4 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/ TNF-alpha pathway in cardiomyocytes.
TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 (show OTX2 Antibodies) and essential retinal pigment epithelium genes.
TNF-alpha induced MMP-13 (show MMP13 Antibodies) expression by condylar cells might be involved in the degradation of the juvenile condyle.
TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.
This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 (show MAMLD1 Antibodies) resistance.
Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (show IL1B Antibodies), IL-8 (show IL8 Antibodies) and TNF-alpha in porcine alveolar macrophages.
the role of miR (show MYLIP Antibodies)-181a in adipocyte differentiation by regulation of TNF-alpha
The NOS (show NOS Antibodies) inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.
Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG (show COL4A1 Antibodies)) enter the spinal cord, they initiate expression of the cytokine TNFalpha. This induction coincides with ensheathment of these axons by associated glia via a TNF receptor 2 (TNFR2 (show TNFRSF1B Antibodies))-mediated process.
The results reveal a crucial role for TNFalpha/TNFR2 (show TNFRSF1B Antibodies) axis in the protection of the skin against DUOX1 (show DUOX1 Antibodies)-mediated oxidative stress.
proinflammatory cytokines IL-1 (show IL1A Antibodies)/TNFalpha trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection.
TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.
The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.
The data suggest that during infectious pancreatic necrosis virus infection, the expression of cytokines and metalloproteinases might be initiated through the TNFalpha/NF-kappaB (show NFKB1 Antibodies)-mediated pathway.
Infectious pancreatic necrosis virus triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNFalpha.
Antisense knockdown of tnfa rescued hepatic steatosis and liver degeneration in dtp (show AHCY Antibodies) larvae, whereas the overexpression of tnfa and the hepatic phenotype were unchanged in dtp (show AHCY Antibodies) larvae.
TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.
The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.
These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.
Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (show CD4 Antibodies)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.
Primary role for IL-1beta (show IL1B Antibodies) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
The results obtained showed that IL-6 (show IL6 Antibodies) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.
Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG (show IFNG Antibodies) and FASL (show FASL Antibodies) regulate nitric oxide activity, via eNOS (show NOS3 Antibodies) expression modulation.
These data show the presence of cytokines TNF and IFNG (show IFNG Antibodies), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (show IL6 Antibodies), IL-10 (show IL10 Antibodies) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.
Inflammatory factors such as TNF-alpha can stimulate MMP-2 (show MMP2 Antibodies)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.
The JNK (show MAPK8 Antibodies) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (show IL8 Antibodies) expression may be regulated by other signaling pathways.
The TNFalpha-evoked Cl- current.
IL-1beta (show IL1B Antibodies) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (show IL1B Antibodies) and TNF-alpha.
Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.
In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (show VEGFA Antibodies) and TNFalpha.
Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (show TGFB1 Antibodies)) and TNF-alpha in lung of rabbits.
TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (show PLAT Antibodies) on the vascular compartment
Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.
Macrophage- and neutrophil-derived TNF-alpha instructs skin langerhans cells to prime antiviral immune responses.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
, TNF, macrophage-derived
, TNF, monocyte-derived
, tumor necrosis factor ligand superfamily member 2
, tumor necrosis factor-alpha
, tumor necrosis factor (TNF superfamily, member 2)
, tumor necrosis factor alpha
, tumor necrosis factor
, tumor-necrosis factor
, tumour necrosis factor
, TNF alpha
, ATP-binding cassette, sub-family F (GCN20), member 1
, tumour necrosis factor alpha
, tumor necrosis factor, alpha
, Tumor necrosis factor ligand superfamily member 2
, TNF-alpha 1