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anti-Human ADAM17 Antibodies:
anti-Mouse (Murine) ADAM17 Antibodies:
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Human Monoclonal ADAM17 Primary Antibody for CyTOF, FACS - ABIN4900516
Breshears, Schlievert, Peterson: A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). in The Journal of biological chemistry 2012
Show all 8 Pubmed References
Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897863
Moreira-Tabaka, Peluso, Vonesch, Hentsch, Kessler, Reimund, Dumont, Muller: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. in PLoS ONE 2012
Show all 5 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for IHC - ABIN965510
Rabie, Strehl, Ludwig, Nieswandt: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. in The Journal of biological chemistry 2005
Show all 12 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for ICC, ELISA - ABIN1003300
Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... in Nature 1997
Show all 4 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for IHC, IHC (p) - ABIN4357504
Sharma, Bender, Zimmermann, Riesterer, Broggini-Tenzer, Pruschy: Secretome Signature Identifies ADAM17 as Novel Target for Radiosensitization of Non-Small Cell Lung Cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Human Polyclonal ADAM17 Primary Antibody for ICC, ELISA - ABIN1003301
Rosendahl, Ko, Long, Brewer, Rosenzweig, Hedl, Anderson, Pyle, Moreland, Meyers, Kohno, Lyons, Lichenstein: Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. in The Journal of biological chemistry 1997
Show all 3 Pubmed References
Human Monoclonal ADAM17 Primary Antibody for IHC (p), PLA - ABIN563080
Kahlert, Weber, Mogler, Bergmann, Schirmacher, Kenngott, Matterne, Mollberg, Rahbari, Hinz, Koch, Aigner, Weitz: Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. in British journal of cancer 2009
Human Polyclonal ADAM17 Primary Antibody for FACS, IF (p) - ABIN705671
Li, Xie, He, Wang, Duan, Yang, Wang: Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis. in Gene 2015
Chicken Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN2478641
Umetsu, Yamashita, Suzuki: Purification and carbohydrate-binding specificities of a blood type B binding lectin from hemolymph of a crab (Charybdis japonica). in Journal of biochemistry 1991
Show all 2 Pubmed References
Human Polyclonal ADAM17 Primary Antibody for FACS, WB - ABIN388309
Tellier, Canault, Poggi, Bonardo, Nicolay, Alessi, Nalbone, Peiretti: HDLs activate ADAM17-dependent shedding. in Journal of cellular physiology 2007
Show all 3 Pubmed References
ADAM17 activation and secretion in the myeloid cells during HIV infection.
A novel ADAM17 inhibitor ZLDI-8 may be a potential chemosensitizer which sensitized CRC (show CALR Antibodies) cells to 5-fluorouracil or irinotecan by reversing Notch (show NOTCH1 Antibodies) and EMT (show ITK Antibodies) pathways.
The isolated membrane proximal domain (MPD (show MVD Antibodies)) of ADAM17 binds to phosphatidylserine (PS) but not to phosphatidylcholine (show SGMS2 Antibodies) liposomes. A cationic PS-binding motif is identified in this domain, replacement of which abrogates liposome-binding and renders the protease incapable of cleaving its substrates in cells.
ADAM-17 in inflammatory myopathy was significantly higher than that in healthy control. ADAM-17 in post-treatment with corticosteroid and/or immunosuppressant serum was significantly decreased compared with that in pre-treatment serum.
The present research suggests that ADAM17shRNA can inhibit MCF7 cell invasion and proliferation in vitro and inhibit MCF7 xenograft growth in vivo through the EGFR (show EGFR Antibodies)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and EGFR (show EGFR Antibodies)/MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling pathways.
Uev1A (show UBE2V1 Antibodies)-Ubc13 (show UBE2N Antibodies) complex catalyzes lysine63-linked ubiquitination of RHBDF2 (show RHBDF2 Antibodies) to promote TACE maturation.
ADAM17 plays a role in chronic kidney disease-mineral and bone disorder.
Insulin-like growth factor-1 (show IGF1 Antibodies) activates different catalytic subunits p110 (show CUX1 Antibodies) of PI3K (show PIK3CA Antibodies) in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 (show ADAM10 Antibodies) and ADAM17.
ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 (show TREM2 Antibodies) after Histidine 157. Findings reveal a link between shedding of TREM2 (show TREM2 Antibodies) and its regulation during inflammatory conditions or chronic neurodegenerative disease in which activity or expression of sheddases might be altered.
Oxidative stress is correlated with hyperactivation of the ADAM17/Notch (show NOTCH1 Antibodies) signaling pathway and a consequent increase in fibrosis in patients with endometriosis.
Report atheroprotective functions of ADAM17 in myeloid cells but atheroprogressive ADAM17 functions in endothelial cells.
results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation.
iRhom2 (show RHBDF2 Antibodies) controls multiple aspects of TACE biology, including stimulated shedding on the cell surface.
Targeting ADAM17 with a lentiviral vector attenuates endotoxemia in mice.
Addition of a disintegrin and metallopeptidase domain 17 (ADAM17) to the culture supernatant of stimulated splenocytes decreased Interferon-gamma (IFN-gamma (show IFNG Antibodies)) concentration.
Overall, iRhom2 (show RHBDF2 Antibodies) binds to TACE throughout its lifecycle, implying that iRhom2 (show RHBDF2 Antibodies) is a primary regulator of stimulated cytokine and growth factor signalling.
Xenoestrogens biphenol-A and nonylphenol stimulate the release of EGFR (show EGFR Antibodies)-ligands by differentially activating ADAM17 or ADAM10 (show ADAM10 Antibodies).
Fhl2 (show FHL2 Antibodies) anticipates the emerging inflammation and specifically the development of psoriatic arthritis by impeding the Adam17-mediated release of TNF (show TNF Antibodies)
most defects in formation of the postnatal epidermal barrier upon keratinocyte-specific ADAM17 deletion are mediated via EGFR (show EGFR Antibodies)
ADAM17 is either not required in T cells under homoeostatic conditions and for control of listeria infection or can be effectively compensated by other mechanisms
these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha (show TNF Antibodies), which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
ADAM17 was involved in porcine CD16 (show CD16 Antibodies) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.
Overexpression of ADAM17 induced downregulation of CD163 (show CD163 Antibodies) expression and a reduction in reproductive and respiratory syndrome virus infection.
activation of TACE/ADAM17 via a PKC (show FYN Antibodies)-induced c-Src (show SRC Antibodies)-dependent manner mediates proteolytic activation of the EGF (show EGF Antibodies)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes
Data indicate that TNF-alpha (show TNF Antibodies) stimulates Rac (show AKT1 Antibodies), ADAM17/TACE, and RhoA (show RHOA Antibodies) through the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) (GEF)-H1 (show ARHGEF2 Antibodies).
progesterone-induced TACE/ADAM17 leads to production of soluble EGF (show EGF Antibodies) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.
ADAM metallopeptidase domain 18
, TNF-alpha convertase
, TNF-alpha converting enzyme
, disintegrin and metalloproteinase domain-containing protein 17
, snake venom-like protease
, tumor necrosis factor, alpha, converting enzyme
, ADAM 17
, TNF-alpha-converting enzyme
, a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme
, a disintegrin and metalloproteinase domain 17
, a disintegrin and metallopeptidase domain 17
, ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, tumor necrosis factor alpha converting enzyme
, ADAM metallopeptidase domain 17
, a disintegrin and metalloprotease domain 17
, disintegrin metalloproteinase
, disintegrin and metalloproteinase domain-containing protein 17-like
, ADAM metallopeptidase domain 17a
, a disintegrin and metalloproteinase domain 17a