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anti-Human AP2A1 Antibodies:
anti-Rat (Rattus) AP2A1 Antibodies:
anti-Mouse (Murine) AP2A1 Antibodies:
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AP-2alpha (show TFAP2A Antibodies) depletion enhanced apoptosis, demonstrating that disrupting the HIV-1 Nef:AP-2alpha interaction limits Nef-mediated apoptosis.
These results lead to a model for the docking of the full AP-2 (show GTF3A Antibodies) tetramer to membranes as bound to Nef, such that the cytosolic tail of CD4 (show CD4 Antibodies) is situated to interact with its binding site on Nef.
AP2alpha negatively regulates HIV-1 replication in the process of nuclear translocation of viral DNA in the cytoplasm or the perinuclear region.
nef usurps AP-2 complexes to dysregulate Ii (invariant chain (Ii)/major histocompatibility complex class II) trafficking and potentially interfere with antigen presentation in the context of MHC-II
SP-A (show SFTPA1 Antibodies) transiently enhances the basal protein expression of CHC (show CLTC Antibodies) and alpha-adaptin (show AP2A2 Antibodies).
AP2 (show TFAP2A Antibodies) protein expression was regulated in a vitamin A-deficiennt mouse developing eye.
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.
100 kDa coated vesicle protein A
, AP-2 complex subunit alpha-1
, adapter-related protein complex 2 alpha-1 subunit
, adaptin, alpha A
, adaptor protein complex AP-2 subunit alpha-1
, alpha-adaptin A
, clathrin assembly protein complex 2 alpha-A large chain
, clathrin-associated/assembly/adaptor protein, large, alpha 1
, plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
, adaptor protein complex AP-2, alpha 1 subunit
, adaptor-related protein complex 2, alpha 1 subunit
, AP-2 complex subunit alpha-1-like
, adaptor-related protein complex AP-2, alpha 1 subunit