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alpha Adaptin Products

(Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))

Categories

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008].

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Featured alpha Adaptin Categories

alpha Adaptin Antibodies

High quality antibodies with extensive validation data.

alpha Adaptin Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended alpha Adaptin Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ELISA, ICC, IHC, WB
Validations
  • (1)
  • (4)
Cat. No. ABIN5539681
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7144361
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, WB
Validations
  • (2)
Cat. No. ABIN6259893
Quantity 100 μL
Datasheet Datasheet

Recommended alpha Adaptin ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6212658
Quantity 96 tests
Datasheet Datasheet

Recommended alpha Adaptin Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3088890
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133146
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1345241
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our alpha Adaptin products

Buser, Ritz, Moes, Tostado, Frank, Spiess, Mariani, Jenö, Boulay, Hutter: "Quantitative proteomics reveals reduction of endocytic machinery components in gliomas." in: EBioMedicine, Vol. 46, pp. 32-41, (2020) (PubMed).

Wu, Xiong, Li, Yang, Ge et al.: "Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid ..." in: Molecular & cellular proteomics : MCP, Vol. 17, Issue 1, pp. 146-159, (2019) (PubMed).

Qureshi, Kaur, Hou, Jeffery, Poulter, Briggs, Kenefeck, Willox, Royle, Rappoport, Sansom: "Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation." in: The Journal of biological chemistry, Vol. 287, Issue 12, pp. 9429-40, (2012) (PubMed).

Rudinskiy, Grishchuk, Vaslin, Puyal, Delacourte, Hirling, Clarke, Luthi-Carter: "Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 12447-58, (2009) (PubMed).

Jarousse, Wilson, Arac, Rizo, Kelly: "Endocytosis of synaptotagmin 1 is mediated by a novel, tryptophan-containing motif." in: Traffic (Copenhagen, Denmark), Vol. 4, Issue 7, pp. 468-78, (2003) (PubMed).

Wasiak, Legendre-Guillemin, Puertollano, Blondeau, Girard, de Heuvel, Boismenu, Bell, Bonifacino, McPherson: "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics." in: The Journal of cell biology, Vol. 158, Issue 5, pp. 855-62, (2002) (PubMed).

Santolini, Puri, Salcini, Gagliani, Pelicci, Tacchetti, Di Fiore: "Numb is an endocytic protein." in: The Journal of cell biology, Vol. 151, Issue 6, pp. 1345-52, (2001) (PubMed).

Jarousse, Kelly: "The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis." in: The Journal of cell biology, Vol. 154, Issue 4, pp. 857-66, (2001) (PubMed).

Teo, Tan, Lim, Manser: "The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors." in: The Journal of biological chemistry, Vol. 276, Issue 21, pp. 18392-8, (2001) (PubMed).

Waelter, Scherzinger, Hasenbank, Nordhoff, Lurz, Goehler, Gauss, Sathasivam, Bates, Lehrach, Wanker: "The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis." in: Human molecular genetics, Vol. 10, Issue 17, pp. 1807-17, (2001) (PubMed).

Synonyms and alternative names related to alpha Adaptin

adaptor related protein complex 2 alpha 1 subunit (AP2A1), adaptor related protein complex 2 alpha 1 subunit (ap2a1), adaptor-related protein complex 2, alpha 1 subunit (Ap2a1), AP-2 complex subunit alpha-1 (EDI_093420), AP-2 complex subunit alpha-1 (EDI_259990), adaptor related protein complex 2 alpha 1 subunit (Ap2a1), ADTAA, adtaa, Adtaa, AP2-ALPHA, ap2-alpha, AP2A1, CLAPA1, clapa1

Protein level used designations for alpha Adaptin

  • 100 kDa coated vesicle protein A
  • AP-2 complex subunit alpha-1
  • adapter-related protein complex 2 alpha-1 subunit
  • adaptin, alpha A
  • adaptor protein complex AP-2 subunit alpha-1
  • alpha-adaptin A
  • alpha1-adaptin
  • clathrin assembly protein complex 2 alpha-A large chain
  • clathrin-associated/assembly/adaptor protein, large, alpha 1
  • plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
  • adaptor protein complex AP-2, alpha 1 subunit
  • adaptor-related protein complex 2, alpha 1 subunit
  • AP-2 complex subunit alpha-1-like
  • adaptor-related protein complex AP-2, alpha 1 subunit
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