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anti-Human JAG1 Antibodies:
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Human Monoclonal JAG1 Primary Antibody for CyTOF, FACS - ABIN4900205
Kibbie, Teles, Wang, Hong, Montoya, Krutzik, Lee, Kwon, Modlin, Cruz: Jagged1 Instructs Macrophage Differentiation in Leprosy. in PLoS pathogens 2016
Show all 5 Pubmed References
Rat (Rattus) Polyclonal JAG1 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900585
Stahl, Uemura, Ge, Shi, Tashima, Stanley: Roles of Pofut1 and O-fucose in mammalian Notch signaling. in The Journal of biological chemistry 2008
Show all 3 Pubmed References
Mouse (Murine) Monoclonal JAG1 Primary Antibody for IHC (fro), FACS - ABIN2480076
McKusick: The Human Genome Project and clinical medicine. in Hospital practice (Office ed.) 1991
Show all 4 Pubmed References
Human Monoclonal JAG1 Primary Antibody for FACS - ABIN4897050
Hoare, Ito, Kang, Weekes, Matheson, Patten, Shetty, Parry, Menon, Salama, Antrobus, Tomimatsu, Howat, Lehner, Zender, Narita: NOTCH1 mediates a switch between two distinct secretomes during senescence. in Nature cell biology 2017
Human Polyclonal JAG1 Primary Antibody for ELISA, ICC - ABIN337168
Siar, Ha, Aung, Nakano, Tsujigiwa, Nagatsuka, Ng, Kawakami: Immunolocalization of notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor. in European journal of medical research 2010
Human Polyclonal JAG1 Primary Antibody for IHC, IHC (p) - ABIN4327850
Gunin, Petrov, Golubtzova, Vasilieva, Kornilova: Age-related changes in angiogenesis in human dermis. in Experimental gerontology 2014
Human Polyclonal JAG1 Primary Antibody for ICC, IF - ABIN269362
Okamoto, Matsuda, Joetham, Lucas, Domenico, Yasutomo, Takeda, Gelfand: Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production. in Journal of immunology (Baltimore, Md. : 1950) 2009
Human Polyclonal JAG1 Primary Antibody for FM, IHC - ABIN129524
Yabe, Matsumoto, Tsurumoto, Shindo: Immunohistological localization of Notch receptors and their ligands Delta and Jagged in synovial tissues of rheumatoid arthritis. in Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2005
The c.765C>T JAG1 variant is significantly associated with the pathogenesis of tetralogy of Fallot in the Iranian population.
Vascular smooth muscle cells were cyclically stretched on flexible membranes, as quantified via video tracking, demonstrating that the expression of Jagged1, Notch3 (show NOTCH3 Antibodies), and target genes was down-regulated with strain.
This study identifies the unique role of JAG1-induced Notch (show NOTCH1 Antibodies) activation in the pathogenesis of multiple myeloma
is an autosomal dominant disorder found to be linked to the Notch ligand (show JAG2 Antibodies) JAG1.5 Approximately 90 percent of patients presenting with Alagille Syndrome have a mutation on the JAG1 gene that is located on chromosome 20p12.
These data indicate a process of NF-kappaB (show NFKB1 Antibodies)-induced miR (show MLXIP Antibodies)-506 suppression and JAG1 upregulation upon IL-1beta (show IL1B Antibodies) induction.
The Jagged1-Notch (show NOTCH1 Antibodies) pathway showed elevated expression in AI-resistant breast cancer cells, resulting in macrophage differentiation towards M2 TAMs and there contributing to the acquisition of AI resistance.
Data show that Delta-like 4 (DLL4) and Jagged1 (JAG1) displayed equal potency in stimulating Notch target genes in HMEC-1 dermal microvascular endothelial cells but had opposing effects on sprouting angiogenesis in vitro.
Missense mutant of Jag1 (Jag1(Ndr (show STK38 Antibodies))) disrupts bile duct development and is responsible for Alagille syndrome phenotypes in heart, eye, and craniofacial dysmorphology.
JAG1 was demonstrated to be a novel target of miR1405p, and miR1405p exerted its inhibitory effect on human glioma growth and invasion, partly by suppressing JAG1.
miR-141 may serve as an antioncomir in GSCs and markedly inhibit their self-renewal via downregulating Jagged1 expression levels in vitro and in vivo.
These findings demonstrate a critical role of osteolineage Jagged1 in bone homeostasis, where Jagged1 maintains the transition of osteoprogenitor to maturing osteoblasts.
Data (including data from studies in transgenic mice) suggest that signaling via Notch2 (show NOTCH2 Antibodies) and Notch3 (show NOTCH3 Antibodies) plays role in promoting cell differentiation and steroidogenesis in preovulatory granulosa cells; mechanism involves regulation of gene expression of Jag1 and Rbpj (show RBPJ Antibodies). (Notch2 (show NOTCH2 Antibodies) = Notch2 (show NOTCH2 Antibodies) receptor; Notch3 (show NOTCH3 Antibodies) = Notch3 (show NOTCH3 Antibodies) receptor; Jag1 = jagged-1 protein; Rbpj (show RBPJ Antibodies) = recombining binding protein suppressor of hairless (show RBPJ Antibodies))
Notch1 signaling is activated in brain endothelial cells cocultured with astrocytes, and astrocytic Jagged1 expression is required for angiogenic enhancement.
loss of Jag1 function in osteoblast lineage cells may contribute to the skeletal phenotype associated with Alagille syndrome.
Epidermal stem cells accelerate diabetic wound healing via the Notch1 (show NOTCH1 Antibodies) signaling pathway; Jag1 overexpression improves diabetic wound healing in vivo.
pre-coated Notch1 (show NOTCH1 Antibodies) protein promotes Notch1 (show NOTCH1 Antibodies)-knocked down B cells to produce antibody in LPS (show TLR4 Antibodies)-stimulated B cells suggesting that Notch1 (show NOTCH1 Antibodies) in other cells may promote antibody production by binding its ligands Dll1 (show DLL1 Antibodies) and Jag1 in B cells.
JAG1 is the main activator of NOTCH signaling and GDNF expression in Sertoli cells.
the effects of two Notch (show NOTCH1 Antibodies) ligands, i.e., Jagged1 and DLL1 (show DLL1 Antibodies), on murine and human hematopoiesis in vitro. Our observations indicate that the stromal expression of Notch (show NOTCH1 Antibodies) ligands increases the production of both the total and phenotypically early murine and human hematopoietic cells in the co-culture.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.
Results indicate that Jagged-Notch (show NOTCH1 Antibodies) signaling is required for segregation between wt1 (show WT1 Antibodies)-expressing cells and differentiated steroidogenic tissue.
Notch (show NOTCH1 Antibodies) pathway is involved in the early steps of thyroid morphogenesis, and Jagged1-Notch (show NOTCH1 Antibodies) signal is required for zebrafish thyroid development and function
Expression of both jagged2 and jagged1b mRNA in the central nervous system suggested that they might be involved in control of differentiating neural progenitors.
Mib-Jag1-Notch (show NOTCH1 Antibodies) signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions
Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch (show NOTCH1 Antibodies) ligands-mediated activation of Notch (show NOTCH1 Antibodies) receptor is involved in the primary neurogenesis
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
, jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1b
, protein jagged-1a
, jagged 1 L homeolog
, C-Serate-1 protein