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Human Polyclonal HMGA1 Primary Antibody for IF (p), IHC (p) - ABIN736626
Uchikura, Matsubara, Muto, Matsubara, Fujioka, Matsumoto, Sugiyama: Extranuclear Translocation of High-Mobility Group A1 Reduces the Invasion of Extravillous Trophoblasts Involved in the Pathogenesis of Preeclampsia. in Reproductive sciences (Thousand Oaks, Calif.) 2017
Human Polyclonal HMGA1 Primary Antibody for IF, WB - ABIN516550
van der Zee, ten Hagen, Hop, van Dekken, Dicheva, Seynhaeve, Koning, Eggermont, van Eijck: Differential expression and prognostic value of HMGA1 in pancreatic head and periampullary cancer. in European journal of cancer (Oxford, England : 1990) 2010
Human Polyclonal HMGA1 Primary Antibody for IHC, ELISA - ABIN185443
Chiappetta, Botti, Monaco, Pasquinelli, Pentimalli, Di Bonito, DAiuto, Fedele, Iuliano, Palmieri, Pierantoni, Giancotti, Fusco: HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression. in Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Show all 2 Pubmed References
Human Polyclonal HMGA1 Primary Antibody for FACS, IF - ABIN653050
Mu, Liu, Zhou, Xu, Jiang, Wang, Qu: Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. in Human pathology 2010
Show all 2 Pubmed References
Human Polyclonal HMGA1 Primary Antibody for ELISA, WB - ABIN451785
Liau, Rocha, Matros, Redston, Whang: High mobility group AT-hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma. in Cancer 2008
High HMGA1 expression is associated with Esophageal Squamous Cell Carcinoma.
The HMGA1 rs139876191 variant played a key role in a protective mechanism against proliferative diabetic retinopathy by downregulating the expression of vascular endothelial growth factor A (VEGFA (show VEGFA Antibodies)), a major activator of neovascularization in diabetic retinopathy.
results from Transwell and woundhealing experiments indicated that HMGA1 participates cell invasion and migration through the ILK/Akt/GSK3beta pathway
Thrombocytosis was more prevalent in patients with inflammatory breast cancer (IBC)than in those with non-IBC and it was associated with poor prognosis. GRO (show CXCL1 Antibodies) and TGF-beta (show TGFB1 Antibodies) were associated with thrombocytosis in IBC.
In this present work, the authors identify and characterize a transcription factor i.e. HIC1 (show HIC1 Antibodies), which physically interacts with both Bcl11b/CTIP2 (show BCL11B Antibodies) and HMGA1 to co-regulate specific subsets of cellular genes and the HIV-1 tat (show TAT Antibodies) gene.
Findings demonstrate that proper subcellular localization of High-mobility group (show SSRP1 Antibodies) A1 (HMGA1) is important for its function in trophoblast cells, and suggest that aberrant cytoplasmic expression of HMGA1 contributes to the pathogenesis of preeclampsia through impairment of trophoblast migration.
these results clearly indicate HMGA1 as a key regulator of the autophagic pathway in cancer cells.
IGF2BP2 (show IGF2BP2 Antibodies) protein is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1.
IL-24 (show IL24 Antibodies) inhibits AKT (show AKT1 Antibodies) via regulating the HMGA1/miR (show MLXIP Antibodies)-222 signaling node in human lung cancer cells and acts as an effective tumor suppressor.
These data reveal an essential role for the molecular chaperone (show HSP90AA1 Antibodies) GRP78 (show HSPA5 Antibodies) in IGF-IR signaling and implicate the use of GRP78 (show HSPA5 Antibodies) inhibitors in blocking IGF-IR signaling in hepatoma cells.
Small interfering RNAs (siRNAs) that specifically target HMGA1 reduced HMGA1 RNA levels and bovine herpesvirus 1 production confirming HMGA1 stimulates productive infection.
HMGA1 likely regulates certain aspects of the BoHV-1 latency-reactivation cycle.
distinct loci exist for growth and fatness in the two populations and identified HMGA1 and PLAG1 (show PLAG1 Antibodies) as strong candidate genes on SSC7 and SSC4, respectively.
Characterization of polymorphisms in the HMGA1 gene in relation to growth and fat deposition.
G9a (show EHMT2 Antibodies) has a novel role in modulating insulin (show INS Antibodies) signaling, at least in part, depending on its regulatory function on HMGA1
Studies define a novel HMGA1-MMP-2 (show MMP2 Antibodies) pathway involved in a subset of human carcinosarcomas and tumor progression in murine models.
Mouse embryonic fibroblasts null for the Hmga1 gene show downregulation of Bub1 (show BUB1 Antibodies), Bub1b (show BUB1B Antibodies), Mad2l1 (show MAD2L1 Antibodies) and Ttk SAC (show ADCY10 Antibodies) genes, and present several features of chromosomal instability, such as nuclear abnormalities, binucleation, micronuclei and karyotypic alterations.
Taken together, our data demonstrate that miR (show MLXIP Antibodies)-625 suppresses cell proliferation and migration by targeting HMGA1 and suggest miR (show MLXIP Antibodies)-625 as a promising prognostic biomarker and a potential therapeutic target for breast cancer.
Inactivation of the Cdkn2a locus cooperates with HMGA1 to drive T-cell leukemogenesis.
Increased HMGA1 expression is associated with pituitary and thyroid tumors.
activated HMGA1 regulates cell proliferation through the Notch1 (show NOTCH1 Antibodies) signaling pathway, which represents an important molecular pathway leading to leukemogenesis.
Data propose that, by affecting the expression of both IGFBP protein species, HMGA1 can serve as a modulator of IGF-I (show IGF1 Antibodies) activity, thus representing an important novel mediator of glucose disposal.
HMGA1 contributes to the neurogenic potential of neural precursor cells in the early stages of neocortical development.
Elevated expression of HMGA1 is associated with the transition of prostate cancer (PCa (show ENPP1 Antibodies)) cells from androgen-sensitive to androgen-independent growth and plays a role in the cell growth of androgen-independent PCa (show ENPP1 Antibodies) cells.
This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.
, high mobility group protein A1
, high mobility group protein HMG-I/HMG-Y
, high mobility group protein R
, high-mobility group (nonhistone chromosomal) protein isoforms I and Y
, nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y
, high mobility group AT-hook protein 1
, high-mobility group AT-hook 1
, high mobility group AT-hook 1
, high mobility group HMGA1A
, high mobility group HMGA1B
, non-histone protein
, high mobility group protein I
, High mobility group AT-hook protein 1
, High mobility group protein A1
, high mobility group-I protein