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Human Polyclonal NR1H4 Primary Antibody for ICC, IF - ABIN152921
Xing, Saner-Amigh, Nakamura, Hinshelwood, Carr, Mason, Rainey: The farnesoid X receptor regulates transcription of 3beta-hydroxysteroid dehydrogenase type 2 in human adrenal cells. in Molecular and cellular endocrinology 2009
Show all 3 Pubmed References
Human Monoclonal NR1H4 Primary Antibody for IF, ELISA - ABIN523347
Chen, Song, Valanejad, Vasilenko, More, Qiu, Chen, Lai, Slitt, Stoner, Yan, Deng: Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2013
Show all 2 Pubmed References
Human Polyclonal NR1H4 Primary Antibody for IF (p), IHC (p) - ABIN1714781
Yang, Mei, Xu, Zhou, Zhu, Sun, Huang, Wang, Shu, Liu, Ding, Hassan, Zhang, Jiang: Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis. in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018
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Human Polyclonal NR1H4 Primary Antibody for ELISA, WB - ABIN188692
Huang, Ma, Zhang, Qatanani, Cuvillier, Liu, Dong, Huang, Moore: Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. in Science (New York, N.Y.) 2006
Human Polyclonal NR1H4 Primary Antibody for WB - ABIN4312873
Lian, Wang, Xiao, Wu, Xu, Liang, Yang: Activated farnesoid X receptor attenuates apoptosis and liver injury in autoimmune hepatitis. in Molecular medicine reports 2015
Cow (Bovine) Polyclonal NR1H4 Primary Antibody for WB - ABIN2773865
Kaeding, Bouchaert, Bélanger, Caron, Chouinard, Verreault, Larouche, Pelletier, Staels, Bélanger, Barbier: Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells. in The Biochemical journal 2008
Show all 2 Pubmed References
Low FXR expression is associated with colorectal cancer.
Studies indicate that the deregulation of farnesoid X receptor (show xpr1 Antibodies) (FXR) may lead to abnormalities of specific organs and metabolic dysfunction [Review].
FXR agonist treatment enhanced TGF-beta (show TGFB1 Antibodies)-induced epithelial mesenchymal transition(EMT (show ITK Antibodies)) morphologic changes and FXR antagonist inhibited the effect of TGF-beta (show TGFB1 Antibodies);. Thus, FXR activation enhances EMT (show ITK Antibodies) in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and FXR antagonists may be EMT (show ITK Antibodies)-suppressing drug candidates.
This study provides some data suggesting the possible involvement of FXR in the pathophysiology and development of thyroid neoplasms. In particular, we found that there are differences regarding FXR expression between papillary carcinomas and hyperplastic nodules, being also correlated with some patients' clinicopathological parameters.
Data suggest that TGR5 (show GPBAR1 Antibodies) and FXR in intestinal mucosa are important for glucose homeostasis, in particular in metabolic disorders such as type 2 diabetes and obesity. (TGR5 (show GPBAR1 Antibodies) = membrane-type receptor for bile acids TGR5 (show GPBAR1 Antibodies); FXR = farnesoid X receptor (show xpr1 Antibodies)) [REVIEW; Congress as Topic]
These results suggested that FXR may serve as an important negative regulator for manipulating Smad3 (show SMAD3 Antibodies) expression, and the FXR/Smad3 (show SMAD3 Antibodies) pathway may be a novel target for the treatment of renal fibros
Loss of FXR or its down-regulation is associated with higher bile acids concentrations and with a pro-tumorigenic phenotype. (Review)
Lys (show LYZ Antibodies)-325 is a non-canonical site of SUMOylation of human FXR.CK2 is the priming effector that phosphorylates Ser (show SIGLEC1 Antibodies)-327, resulting in enhanced SUMO2 (show SUMO2 Antibodies) conjugation, which then directs the ubiquitination and degradation of FXR through the recruitment of the SUMO-dependent ubiquitin E3 ligase RNF4 (show RNF4 Antibodies).
we proposed a model to link FXR to Sp1 (show PSG1 Antibodies), which included triggered FXR, p38/MAPK (show MAPK14 Antibodies) and/or PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and phosphorylated Sp1 (show PSG1 Antibodies), to illustrate the potential crosstalk between the two factors.
the presented evidence suggested that WA can inhibit HCC (show FAM126A Antibodies) cell proliferationand tumorigenesis through miR (show MLXIP Antibodies)-22-repressed CCNA2 (show CCNA2 Antibodies), which was at least partially through FXR regulation
results suggest that hypothyroidism induces a moderate non-alcoholic steatohepatitis, alllowing the hepatic regeneration. The FXRalpha may be involved in the development of non-alcoholic steatohepatitis in hypothyroid subjects.
FXR is expressed in the ovary, in all regions of the oviduct, and all portions of the vagina of rabbits.
The role of the CAR signaling pathways within testis was validated using specific CAR agonist (TCPOBOP) and inverse agonist (androstanol) that respectively inhibited or reproduced the phenotype observed in Fxralpha-/- males fed Bile acids (BAs)-diet. These data open interesting perspectives to better define how BA homeostasis contributes to physiological or pathophysiological conditions via the modulation of CAR activity.
Study identified an FXR/beta-catenin (show CTNNB1 Antibodies) interaction whose modulation through beta-catenin (show CTNNB1 Antibodies) suppression promotes FXR activation and decreases hepatic bile acids, which may provide unique therapeutic opportunities in cholestatic liver diseases
Farnesoid X receptor (show xpr1 Antibodies) gene deficiency impairs urine concentration in renal medulla.
Data, including data from studies using knockout mice, suggest that control of whole-body energy expenditure by Gcgr (show GCGR Antibodies) agonism requires intact Fxr signaling and Fgf21 (show FGF21 Antibodies) secretion in liver. (Gcgr (show GCGR Antibodies) = glucagon receptor (show GCGR Antibodies) glucagon (show GCG Antibodies); Fxr = farnesoid X receptor (show xpr1 Antibodies); Fgf21 (show FGF21 Antibodies) = fibroblast growth factor-21 (show FGF21 Antibodies))
FXR exerts its function in L cells through interacting with CREB (show CREB1 Antibodies), a crucial transcriptional regulator of cAMP-CREB (show CREB1 Antibodies) signaling pathway, to inhibit its transcriptional activity. Targeting FXR to rescue GLP-1 (show GCG Antibodies) secretion may be a promising strategy for type II diabetes.
The underlying mechanism of curcumin against cholestasis was restoring bile acid homeostasis and antagonizing inflammatory responses in a FXR-dependent manner and in turn contributed to overall cholestasis attenuation.
FXR alpha helps establish and maintain an undifferentiated germ cell pool and in turn influences male fertility. FXR alpha controls the expression of the pluripotency marker Lin28 (show LIN28A Antibodies) in the germ cells.
FXR signaling is a bile acid nuclear receptor that regulates lipids and glucose homeostasis and lack of it causes hepatomegaly and liver dysfunction.
These results suggest that lack of FXR impaired FoxO3a (show FOXO3 Antibodies)-mediated autophagy and in turn exacerbated alcohol-induced liver injury
alterations in bile acid composition may have contributed to the observed disturbance in FXR-mediated signalling pathways in short bowel syndrome-associated liver disease
FXR splice variant has a dominant positive effect on wild type FXR.
In conclusion, PXR (show NR1I2 Antibodies) and FXR both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR (show NR1I2 Antibodies) and FXR transactivation at in vivo expression levels.
This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
nuclear receptor subfamily 1, group H, member 4
, orphan nuclear receptor FOR2
, bile acid receptor
, farnesoid X activated receptor
, bile acid receptor-like
, RXR-interacting protein 14
, farnesoid X nuclear receptor
, farnesoid X-activated receptor
, farnesol receptor HRR-1
, retinoid X receptor-interacting protein 14
, nuclear receptor subfamily 1 group H member 4