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anti-Human NOXA Antibodies:
anti-Mouse (Murine) NOXA Antibodies:
anti-Rat (Rattus) NOXA Antibodies:
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Human Monoclonal NOXA Primary Antibody for ICC, IF - ABIN269360
Deverman, Cook, Manson, Niederhoff, Langer, Rosová, Kulans, Fu, Weinberg, Heinecke, Roth, Weintraub: Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. in Cell 2002
Show all 63 Pubmed References
Human Monoclonal NOXA Primary Antibody for ELISA - ABIN4235450
van Gent, Kater, Otto, Jaspers, Borghans, Vrisekoop, Ackermans, Ruiter, Wittebol, Eldering, van Oers, Tesselaar, Kersten, Miedema: In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow. in Cancer research 2008
Show all 29 Pubmed References
Human Polyclonal NOXA Primary Antibody for IHC (p), WB - ABIN4340476
Eno, Zhao, Venkatanarayan, Wang, Flores, Li: Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress. in Free radical biology & medicine 2013
Show all 5 Pubmed References
Human Polyclonal NOXA Primary Antibody for WB - ABIN223344
Li, Chen, Clifton, Sullivan, Dalton, Gabrilovich, Nefedova: Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect. in Molecular cancer therapeutics 2010
Show all 3 Pubmed References
Human Polyclonal NOXA Primary Antibody for IHC, ELISA - ABIN1031489
Rath, Das, Kokate, Pratheek, Chattopadhyay, Goswami, Chattopadhyay, Crowe, Bhattacharyya: Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
Show all 2 Pubmed References
Human Polyclonal NOXA Primary Antibody for ELISA, ICC - ABIN4340478
Bai, Ahmad, Wang, Li, Choy, Kim, Kirkiles-Smith, Maher, Karras, Bennett, Bothwell, Pober, Tellides: Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. in The Journal of biological chemistry 2008
Human Polyclonal NOXA Primary Antibody for ICC, IF - ABIN4340477
Kelly, Espitia, Mahalingam, Oyajobi, Coffey, Giles, Carew, Nawrocki: Reovirus therapy stimulates endoplasmic reticular stress, NOXA induction, and augments bortezomib-mediated apoptosis in multiple myeloma. in Oncogene 2012
Human Polyclonal NOXA Primary Antibody for ELISA, WB - ABIN2475926
Sowter, Slavin, Sowter, Rosen, Hendry: Morphometry of bladder carcinoma: morphometry and grading complement each other. in Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 1991
Show all 2 Pubmed References
Human Polyclonal NOXA Primary Antibody for IHC (p), WB - ABIN2475927
Pinto, Ware, Hampsey: The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo. in Cell 1992
Show all 2 Pubmed References
Therefore, the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
By ubiquitylating and degrading NOXA through activating CRL5, UBE2F (show UBE2F Antibodies) selectively promotes lung cancer cell survival and could, therefore, serve as a novel cancer target
Data show that Noxa-mediated MCL-1 (show MCL1 Antibodies) phosphorylation and degradation is regulated by CDK2 (show CDK2 Antibodies).
the c-FLIP (show CFLAR Antibodies) and NOXA/Mcl-1 (show MCL1 Antibodies) axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells
Noxa is involved in X-ray-induced lung injury.
Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and acts synergistically with antimicrotubule drugs.
knockdown of MCL-1 (show MCL1 Antibodies) in MRT cell lines induced apoptosis and increased DOX sensitivity in malignant rhabdoid tumor cells
high levels of miR21 expression may induce gastric cancer migration and invasion via the downregulation of Noxa expression
Inhibition of SIRT1 (show SIRT1 Antibodies) could induce the Noxa expression in A549/DDP (show TIMM8A Antibodies) cells.
Fluorizoline bind to prohibitin (show PHB Antibodies), inducing mitochondrial apoptotic pathway through NOXA and BIM (show BCL2L11 Antibodies) upregulation.
Noxa demethylation has a role in Bortezomib resistance in mantle cell lymphoma
knockdown of pmaip1 mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.
In vivo upregulation of noxa was reduced by pifithrin-alpha, suggesting transcription may be partly p53 (show TP53 Antibodies)-dependent.The present findings indicate Noxa does not serve as a proapoptotic BH3-only protein (show BAD Antibodies) during seizure-induced neuronal death in vivo
In addition, studies in leukemia Jurkat T cells support the existence of the Sall2 (show SALL2 Antibodies)/Noxa axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Our data demonstrate that ES cells are uniquely sensitive to CDK1 (show CDK1 Antibodies) inhibition via a p53 (show TP53 Antibodies)/NOXA/MCL1 (show MCL1 Antibodies) pathway.
Overall, these data reveal a Noxa-mediated signaling pathway that couples lysosomal membrane permeabilization with mitochondrial outer membrane permeabilization and ultimate apoptosis during oxidative stress.
by preventing the consumption of IL-15 (show IL15 Antibodies), Bim (show BCL2L11 Antibodies) limits the role of Noxa and Puma (show BBC3 Antibodies) in causing the death of effector cells with less memory potential.
Induction of noxa does not influence ischemic neuronal injury.
the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
phorbol-12-myristate-13-acetate-induced protein 1
, PMA-induced protein 1
, adult T cell leukemia-derived PMA-responsive
, immediate-early-response protein APR
, protein Noxa