NOXA antibody (AA 21-54)

Catalog No. ABIN873278

The Rabbit Polyclonal anti-NOXA antibody is suitable to detect NOXA in samples from Human. It has been validated for IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for NOXA antibody (AA 21-54) (ABIN873278)

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOXA antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-NOXA Antibody

Binding Specificity: AA 21-54

Purpose: Noxa Polyclonal Antibody

Predicted Reactivity: Human,Mouse,Rat,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Noxa

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NOXA

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Alternative Name: Noxa

Background:

Synonyms: Adult T cell leukemia derived PMA responsive, APR, APR_HUMAN, Immediate early response protein APR, Immediate-early-response protein APR, Phorbol 12 myristate 13 acetate induced protein 1, Phorbol-12-myristate-13-acetate-induced protein 1, PMA induced protein 1, PMA-induced protein 1, PMAIP1, Protein Noxa.

Background: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Gene ID: 5366

Pathways: p53 Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus