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anti-Mouse (Murine) SERPINB5 Antibodies:
anti-Human SERPINB5 Antibodies:
anti-Rat (Rattus) SERPINB5 Antibodies:
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Cow (Bovine) Polyclonal SERPINB5 Primary Antibody for IHC, WB - ABIN2777125
Vereecken, Reynaert, Lalmand, Zouaoui-Boudjeltia, Heenen, Van Den Heule, Petein: Decreased immunoreactive maspin expression in intermediate thickness and thick primary melanoma lesions. in The Journal of international medical research 2006
Show all 4 Pubmed References
Human Polyclonal SERPINB5 Primary Antibody for IF, IHC (p) - ABIN656020
Kim, Jang, Kim, Park, Chang, Lee, Lee, Heo, Choi, Choi, Rhee, Lee: Aberrant maspin expression is involved in early carcinogenesis of gallbladder cancer. in Tumour biology 2010
Show all 3 Pubmed References
Human Polyclonal SERPINB5 Primary Antibody for ICC, IHC (p) - ABIN3043330
Yang, Shi, Li, Yi: Effects of shRNA targeting maspin on invasion of gastric carcinoma SGC7901 cell line. in Oncology reports 2010
Show all 2 Pubmed References
Human Polyclonal SERPINB5 Primary Antibody for IF (p), IHC (p) - ABIN728233
Sun, Wu, Ruan, Zheng, Song, Zhun, Wu, Gotlieb: Expression patterns of maspin and mutant p53 are associated with the development of gestational trophoblastic neoplasia. in Oncology letters 2016
maspin is a powerful context-dependent tumor suppressor.
these data indicate that SerpinB5 expression and phosphorylation are developmentally regulated. In vitro analyses indicate that SerpinB5 phosphorylation is regulated by EGFR (show EGFR Antibodies) ligands, but EGF (show EGF Antibodies) appears to be the only able to induce SerpinB5 nuclear localization.
perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression
evidence demonstrates that D(346) is a critical cis (show CISH Antibodies)-element in maspin sequence that determines the molecular context and subcellular localization of maspin.
a novel mechanism by which maspin utilizes its cysteine thiols to inhibit oxidative stress and cell growth.
results suggest that maspin, a tumor suppressor, may play an important role in embryo implantation
The nuclear localization of maspin is required for its tumor and metastasis suppressor functions in vivo.
SERPINB5 and AKAP12 (show AKAP12 Antibodies) may have a role in increased metastasis in pancreatic ductal adenocarcinoma
PAR-1 (show MARK2 Antibodies) negatively regulates the expression of the Maspin tumor-suppressor gene in the acquisition of the metastatic melanoma phenotype
Results describe a mechanism by which maspin exerts its effect on endothelial cell adhesion and migration through an integrin signal transduction pathway.
data suggest that maspin inhibits high glucose-induced proliferation, oxidative stress, and angiogenesis of HRMECs at least by modulating the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway. Maspin may be a potential therapeutic agent for the prevention and treatment of proliferative diabetic retinopathy.
SERPINB5 may play an important role in rectal cancer progression and response to neoadjuvant CCRT and serve as a novel prognostic factor.
maspin expression has a prognostic role in breast cancer. Maspin expression is related to increased angiogenesis. Subcellular localization of maspin can strongly affect cancer prognosis. Cytoplasmic maspin relates to poor prognostic parameters whereas nuclear maspin relates to good prognostic ones.
Maspin nuclear expression in colorectal carcinoma buds may be helpful for a proper budding assessment and may serve as a negative prognostic factor.
The expression of maspin in the cytoplasm alone could be useful for predicting unfavorable prognoses in patients with p-stage IA lung adenocarcinoma
The severity of hip OA can be related to angiogenesis pathways that are not maspin-mediated.
SNPs affected SERPINB5 expression and protein stability, which significantly correlated with tumour expression and subsequently with tumour development and aggressiveness. Taken together, our findings regarding these biomarkers provide a prediction model for risk assessment.
Maspin is spontaneously secreted as an exosomal protein to regulate tumor/stromal interactions.
Study results provide new insights into the molecular mechanisms of maspin suppression in response to HBx, and revealed nuclear IKKalpha (show CHUK Antibodies) as a prognostic biomarker and a potential therapeutic target to improve the clinical outcome of HBV-associated HCC (show FAM126A Antibodies) patients.
Mechanistic investigations found that quercetin suppressed Snail (show SNAI1 Antibodies)-dependent Akt (show AKT1 Antibodies) activation by upregulating maspin and Snail (show SNAI1 Antibodies)-independent a disintegrin and metalloproteinase (ADAM) 9 (show ADAM9 Antibodies) expression pathways to modulate the invasive ability of NSCLC cells.
may act as a tumor suppressor
peptidase inhibitor 5
, protease inhibitor 5
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
, serine (or cysteine) proteinase inhibitor, clade B, member 5
, serine protease inhibitor 7
, serpin B5
, protease inhibitor 5 (maspin)
, serine (or cysteine) peptidase inhibitor, clade B, member 5