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anti-Human SERPINE1 Antibodies:
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Human Polyclonal SERPINE1 Primary Antibody for ELISA, ICC - ABIN446967
Berard, Déglise, Alonso, Saucy, Meda, Bordenave, Corpataux, Haefliger: Role of hemodynamic forces in the ex vivo arterialization of human saphenous veins. in Journal of vascular surgery 2013
Show all 8 Pubmed References
Mouse (Murine) Polyclonal SERPINE1 Primary Antibody for ELISA (Detection), IHC (p) - ABIN491336
Weisberg, Albornoz, Griffin, Crandall, Elokdah, Fogo, Vaughan, Brown: Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling. in Arteriosclerosis, thrombosis, and vascular biology 2005
Show all 7 Pubmed References
Chimpanzee Polyclonal SERPINE1 Primary Antibody for IHC (p), ELISA - ABIN2476046
Faber, Lorimier, Sergysels: Cyclic haemodynamic and arterial blood gas changes during Cheyne-Stokes breathing. in Intensive care medicine 1990
Show all 4 Pubmed References
Mouse (Murine) Polyclonal SERPINE1 Primary Antibody for ELISA (Detection), WB - ABIN490932
Obi, Diaz, Ballard-Lipka, Roelofs, Farris, Lawrence, Henke, Wakefield: Low-molecular-weight heparin modulates vein wall fibrotic response in a plasminogen activator inhibitor 1-dependent manner. in Journal of vascular surgery. Venous and lymphatic disorders 2014
Show all 3 Pubmed References
Human Polyclonal SERPINE1 Primary Antibody for IHC, IHC (p) - ABIN4352929
Rice, Padilla, McLaughlin, Mathes, Ziemek, Goummih, Nakerakanti, York, Farina, Whitfield, Spiera, Christmann, Gordon, Weinberg, Simms, Lafyatis: Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. in The Journal of clinical investigation 2015
Show all 3 Pubmed References
Human Monoclonal SERPINE1 Primary Antibody for FACS, IHC - ABIN969566
Oh, Olman, Benveniste: CXCL12-mediated induction of plasminogen activator inhibitor-1 expression in human CXCR4 positive astroglioma cells. in Biological & pharmaceutical bulletin 2009
Show all 2 Pubmed References
Mouse (Murine) Polyclonal SERPINE1 Primary Antibody for ELISA (Detection), IHC (p) - ABIN491337
Darehzereshki, Rubin, Gamba, Kim, Fraser, Huang, Billings, Mohammadzadeh, Wood, Warburton, Kaartinen, Lien: Differential regenerative capacity of neonatal mouse hearts after cryoinjury. in Developmental biology 2015
Show all 2 Pubmed References
Human Polyclonal SERPINE1 Primary Antibody for ELISA (Detection), IHC (p) - ABIN490950
Devin, Johnson, Eren, Gleaves, Bradham, Bloodworth, Vaughan: Transgenic overexpression of plasminogen activator inhibitor-1 promotes the development of polycystic ovarian changes in female mice. in Journal of molecular endocrinology 2007
Show all 2 Pubmed References
Human Polyclonal SERPINE1 Primary Antibody for IHC, ELISA - ABIN185384
Baumruker, Csonga, Pursch, Pfeffer, Urtz, Sutton, Bofill-Cardona, Cooke, Prieschl: Activation of mast cells by incorporation of cholesterol into rafts. in International immunology 2003
Show all 2 Pubmed References
Human Polyclonal SERPINE1 Primary Antibody for WB - ABIN518599
Yentrapalli, Azimzadeh, Barjaktarovic, Sarioglu, Wojcik, Harms-Ringdahl, Atkinson, Haghdoost, Tapio: Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low-dose rate gamma radiation. in Proteomics 2013
The analysis of genotype coexistence revealed a higher incidence of the combination of the ACE (show ACE Antibodies) II and the PAI-1 4G/4G genotypes in the control group (10.0 vs.5.9% in control group; p = 0.17). CONCLUSIONS: The obtained results suggest no apparent association between the ACE (show ACE Antibodies) I/D, PAI-1 4G/5G polymorphisms and increased RM susceptibility in the analyzed Polish population.
Serum PAI-1 level at the time of traumatic brain injury may serve as a predictive biomarker of late pituitary dysfunction in mild traumatic brain injury patients.
The personalization of the patients' treatment using uPA (show PRAP1 Antibodies)/PAI-1 tumor levels allows the reversion of the well-known poor prognostic impact of high uPA (show PRAP1 Antibodies)/PAI-1 levels and strongly supports the use of this biomarker in clinical practice.
Data show that plasminogen activator inhibitor-1 (PAI-1) and chemokine (show CCL1 Antibodies) CCL5 (CCL5 (show CCL5 Antibodies)) overexpression promoted cell proliferation and migration in breast cancer cells.
Multiple sclerosis patients were categorized as not cognitively impaired (NCI) and cognitively impaired (CI). The NCI group had a higher percentage of heterozygous subjects but no statistical differences were found between the CI and NCI group. Neuropsychological functioning did not correlate with plasma levels of PAI-1 or its genetic polymorphism. PAI-1 plasma levels were related to neurological impairment.
Results demonstrated that EMT (show ITK Antibodies) could promote the secretion of PAI-1 in the triple negative breast cancer (TNBC) cells. TNBC-secreted PAI-1 could increase cell growth, migration and invasion, and the expression of EMT (show ITK Antibodies) markers in the TNBC cell lines and xenograft mice model. Most importantly, PAI-1 expression is significantly elevated in the breast cancer tissues and associated with prognosis of patients with TNBC.
Plasma PAI-1 levels may be determined by the degree of obesity and triglyceride metabolic disorders. These factors correlate with a decreased LDL-particle size, increasing the risk of atherosclerosis.
In this meta-analysis, it was determined that PAI-1 polymorphism confers a genetic contribution to the development of recurrent spontaneous abortion.
The A allele and AA genotype of rs6092 in SERPINE 1 may protect against T2 diabetes, and have a protective effect on waist circumference, but a negative effect on Triglycerides in men, while may contribute to a lower HbA1c level in women.
Adjuvant chemotherapy was 9% less likely to be recommended by a multidisciplinary board when using the current criteria compared with using a combination of the St. Gallen criteria and Ki67 (show MKI67 Antibodies) and uPA (show PRAP1 Antibodies)/PAI-1 status (P = 0.03). Taken together, our data show discordance among markers in identifying the risk of recurrence, even though each marker may prove to be independently valid.
The serpin PN1 (show SCN9A Antibodies) is a feedback regulator of FGF signaling in germ layer and primary axis formation.
a highly dynamic endocardium in the regenerating zebrafish heart, with two key endocardial players, Serpine1 and Notch (show NOTCH1 Antibodies) signalling, regulating crucial regenerative processes, is reported.
SERPINe1-derived 14-mer (show MERTK Antibodies) peptide and low molecular weight drugs targeting SERPINe1 (i.e. tannic acid, EGCG, tiplaxtinin) inhibited in vitro infections not only of viral haemorrhagic septicemia virus, but also of other fish rhabdoviruses.
X-ray crystal structure analysis of glycosylated fish PAI-1 confirmed the presence of an N-linked glycan in the gate region and a lack of glycan-induced structural changes.
The effects of genetic alterations in PAI-1 expression, pharmacologic PAI-1 inhibition and recombinant PAI-1 on smooth muscle cell vitronectin (VN (show VTN Antibodies)) expression were studied, and vascular VN expression in wild-type and PAI-1-deficient mice was assessed.
PAI-1 deficiency accelerates subchondral osteopenia after induction of osteoarthritis.
PAI-1 induces alveolar type II cell senescence through activating p53 (show TP53 Antibodies)-p21 (show D4S234E Antibodies)-Rb pathway in fibrotic lung disease.
paracrine PAI-1 is involved in glucocorticoid-induced muscle wasting through the enhancement of muscle degradation in mice.
day-night feeding cycle is not a critical Zeitgeber for circadian rhythm of circulating PAI-1
PAI-1 is an in vivo target of the Pla protease in the lungs, and PAI-1 is a key regulator of the pulmonary innate immune response
the role of the antifibrinolytic protein plasminogen activator inhibitor-1 (PAI-1) in alcohol enhancement of experimental endotoxin-induced acute lung injury, is reported.
PAI-1 inhibitor PAI-039 prevents smooth muscle cell migration and neointimal hyperplasia.
Tongqiaohuoxue decoction exerted an anti-thrombotic effect through the regulation of PAI-1 and fibrinolysis.
PAI-1 plays a role in maintaining gastric mucosal organization in hypergastrinemia.
In one pig population and in female pigs, SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) was significantly associated with muscling, growth and fat accretion and in male animals with meat quality.
Data show that urokinase-type plasminogen activator (uPA (show PLAU Antibodies)) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA (show PLAU Antibodies) receptor (uPAR (show PLAUR Antibodies)) and plasminogen activator inhibitor-1 (PAI-1) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue/stress stimulation.
the PI3K/Akt (show AKT1 Antibodies) pathway acts as a negative regulator of PAI-1 expression in vascular endothelial cells, in part, through the downregulation of MAPK (show MAPK1 Antibodies) pathways
high glucose-induced plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells is mediated by NF-kappaB (show NFKB1 Antibodies) activation through the Rho/Rho-kinase (show ROCK1 Antibodies) pathway
FoxO1 (show FOXO1 Antibodies) inhibits PAI-1 expression through the inhibition of TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies)-mediated signaling pathways.
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endothelial plasminogen activator inhibitor
, plasminogen activator inhibitor 1
, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
, serpin E1
, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
, PAI 1
, serine (or cysteine) proteinase inhibitor, clade E, member 1
, putative plasminogen activator inhibitor-1
, chemokine CCL-C25s
, plasminogen activator inhibitor 1-like
, Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
, nexin, plasminogen activator inhibitor type 1
, plasminogen activator inhibitor, type I
, serine (or cysteine) peptidase inhibitor, clade E, member 1
, serine (or cysteine) proteinase inhibitor, member 1
, plasminogen activator inhibitor I
, plasminogen activator inhibitor type 1
, plasminogen activator inhibitor, type 1
, plasminogen activator inhibitor-1