PAI1 antibody

Catalog No. ABIN969566

There are 2+ publications for this product available. The Mouse Monoclonal anti-PAI1 antibody is suitable to detect PAI1 in samples from Human. It has been validated for IHC, ELISA and FACS.

Quick Overview for PAI1 antibody (ABIN969566)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAI1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 1D5

Product Details anti-PAI1 Antibody

Purpose: SERPINE1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human SERPINE1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PAI1 antibody (ABIN969566)

Oh, Olman, Benveniste: "CXCL12-mediated induction of plasminogen activator inhibitor-1 expression in human CXCR4 positive astroglioma cells." in: Biological & pharmaceutical bulletin, Vol. 32, Issue 4, pp. 573-7, (2009) (PubMed).

Zee, Bubes, Shrivastava, Ridker, Glynn: "Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach." in: Clinica chimica acta; international journal of clinical chemistry, Vol. 402, Issue 1-2, pp. 189-92, (2009) (PubMed).

Target Details for PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Alternative Name: SERPINE1

Background: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 45 kDa

UniProt: P05121

Pathways: p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration