anti-Interleukin 1 alpha (IL1A) antibody pair
Quick Overview for anti-Interleukin 1 alpha (IL1A) antibody pair (ABIN1305225)
Target
Reactivity
Host
Clonality
Application
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Method Type
- Sandwich ELISA
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Detection Range
- 15.6-2000 pg/mL
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Minimum Detection Limit
- 15.6 pg/mL
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Specificity
- Detects mouse IL-1alpha.
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No Cross-Reactivity
- Human
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Cross-Reactivity (Details)
- Does not detect human IL-1alpha or mouse IL-1beta.
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Sensitivity
- 10 pg/mL
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Components
- 1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (120μg) [COAT] 1 vial detection antibody (30μg) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
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IL1A (Human) Matched Antibody Pair
ELISA Reactivity: Human ELISA unconjugated Host: Mouse
IL1A (Human) Matched Antibody PairELISA Reactivity: Human ELISA unconjugated Host: Rabbit, Mouse
IL1A (Human) IP-WB Antibody PairIP Reactivity: Human IP unconjugated Host: Rabbit, Mouse
IL1A (Human) Matched Antibody PairELISA Reactivity: Human ELISA unconjugated Host: Rabbit, Mouse
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Restrictions
- For Research Use only
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Concentration
- Lot specific
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Storage
- -20 °C
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Storage Comment
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Short Term Storage: -20°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
Expiry Date
- 12 months
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- IL1A (Interleukin 1 alpha (IL1A))
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Alternative Name
- IL-1alpha
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Background
- The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
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UniProt
- P01582
Target
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