CD4 FITC - CD28 PE Bi-Test Reagent
FACS
Reactivity: Human
FACS
FITC,PE
Host: Mouse
Quick Overview for CD4 FITC - CD28 PE Bi-Test Reagent (ABIN2763724)
Target
CD4 + CD28
Reactivity
Human
Host
Mouse
Conjugate
FITC,PE
Application
Flow Cytometry (FACS)
-
-
Brand
- Bi-Test™
-
Purification
- Protein A/G Chromatography
-
Isotype
- IgG1
-
-
-
Restrictions
- For Research Use only
-
-
-
Storage
- 4 °C
-
-
- CD4 + CD28
-
Alternative Name
- CD4, CD28
-
Background
- Identification of CD4 on human helper/inducer T cells expressing the 60,000 M.W. surface antigen (HLA class II reactive). CD4 is present in low density on monocytes. Anti-human CD28 binds the 44 kDa MW cell surface protein on the surface of most T cells. CD28 acts as the ligand for the B7/BB-1 Molecule on the surface of activated B cells. B7/BB-1 co-stimulates T cells through CD28, along with CD2 and CD3. CD28 antigen is a disulfide-linked homodimeric glycoprotein. The CD28 antigen is present on approximately 60 % -80 % of lymphocytes (95 % of CD4 and 50 % of CD8 lymphocytes). CD28 regulates the expression of cytokines by T cells, not only IL-2, but also IL-1 alpha and CSF-1, usually synthesized by accessory cells. CD28 functions as a cell adhesion molecule (CAM) for certain T cell subsets.
Target
-
You are here:
