PDL1 Detection Set
ELISA, FACS, ICC
Reactivity: Human
ELISA, FACS, ICC
unconjugated
AA 19-239
Host: Llama
Monoclonal
Quick Overview for PDL1 Detection Set (ABIN6251784)
Target
PD-L1
(CD274 (PD-L1))
Binding Specificity
AA 19-239
Reactivity
Human
Host
Llama
Clonality
Monoclonal
Application
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
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Fragment
- single-domain Antibody (sdAb)
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Characteristics
- Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.
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Purification
- PD-L1 Antibodies are affinity chromatography purified via Nickel column.
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Components
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PD-L1 Antibody [F1A12]
PD-L1 Antibody [F1C9]
PD-L1 Antibody [F6A9]
PD-L1 Antibody [F2G2] -
Immunogen
- PD-L1 antibodies were raised against a recombinant protein corresponding to amino acids 19 - 239 of human PD-L1.
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CD274 (Human) Matched Antibody Pair
ELISA Reactivity: Human ELISA unconjugated Host: Mouse
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- PD-L1 Antibodies are supplied in PBS containing 0.02 % sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- PD-L1 (CD274 (PD-L1))
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Alternative Name
- PDL1
Target
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