PDL1 Detection Set (Risk Free)
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- Target See all PD-L1 products
- PD-L1 (CD274 (PD-L1))
- Binding Specificity
- Extracellular Domain
- Reactivity
- Human
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Host
- Mouse
- Clonality
- Monoclonal
- Application
- ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Immunofluorescence (IF)
- Brand
- Risk-Free™
- Characteristics
- Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.
- Purification
- Antibodies are supplied as protein A purified IgG1.
- Components
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PD-L1 Antibody [4F2]
PD-L1 Antibody [8E12]
PD-L1 Antibody [6H10]
PD-L1 Antibody [2D6]
PD-L1 Antibody [1F11]
PD-L1 Antibody [1D7] - Immunogen
- PD-L1 antibodies were raised against the extracellular domain of human PD-L1.
- Isotype
- IgG1
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CD274 (Human) Matched Antibody Pair
ELISA Reactivity: Human ELISA unconjugated Host: Mouse
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- Comment
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Risk-Free™ antibodies are monoclonal antibodies made to improve in vitro studies.
Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free™ antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein.
These antibodies have the following advantages:
- Antibodies are developed against mammalian-expressed, post-translationally modified recombinant proteins.
- Multiple antibodies per target allows the user to choose the best antibody for their application
- Available individually or as a set
- Risk-Free™ means they are rigorously tested and guaranteed to work for their designated applications:
- ELISA
- Flow Cytometry
- Immunoblot
- Immunohistochemistry
- Immunocytochemistry
- Immunofluorescence - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Target
- PD-L1 (CD274 (PD-L1))
- Alternative Name
- PDL1 (PD-L1 Products)
- Synonyms
- B7-H Matched Antibody Pair, B7H1 Matched Antibody Pair, PD-L1 Matched Antibody Pair, PDCD1L1 Matched Antibody Pair, PDCD1LG1 Matched Antibody Pair, PDL1 Matched Antibody Pair, A530045L16Rik Matched Antibody Pair, B7h1 Matched Antibody Pair, Pdcd1l1 Matched Antibody Pair, Pdcd1lg1 Matched Antibody Pair, Pdl1 Matched Antibody Pair, RGD1566211 Matched Antibody Pair, CD274 molecule Matched Antibody Pair, CD274 antigen Matched Antibody Pair, programmed cell death 1 ligand 2 Matched Antibody Pair, CD274 Matched Antibody Pair, Cd274 Matched Antibody Pair, PDCD1LG2 Matched Antibody Pair
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