(serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1))
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011].
Deng, Gui, Kim, Xie, Chen, Li, He, Chen, Chen, Luo, Lu, Xie, Churchill, Xu, Zhou, Wu, Yu, John, Hirayasu, Nguyen, Liu, Huang, Li, Deng, Tang, Sadek, Zhang, Huang, Zou, Chen, Zhu, Arase, Xia, Jiang et al.: "LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. ..." in: Nature, Vol. 562, Issue 7728, pp. 605-609, (2019) (PubMed).
Zhang, Dai, Neng, Zhang, Zhi, Fridberger, Shi: "Perivascular macrophage-like melanocyte responsiveness to acoustic trauma--a salient feature of strial barrier associated hearing loss." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 9, pp. 3730-40, (2013) (PubMed).
Aliases for PEDF Proteins
serpin family F member 1 (SERPINF1) Proteins serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (serpinf1) Proteins serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog (serpinf1.L) Proteins serpin family F member 1 (Serpinf1) Proteins serine (or cysteine) peptidase inhibitor, clade F, member 1 (Serpinf1) Proteins AI195227 Proteins Dmrs91 Proteins EPC-1 Proteins MGC82984 Proteins OI6 Proteins OI12 Proteins PEDF Proteins Pedf Proteins Pedfl Proteins Sdf3 Proteins SERPINF1 Proteins zgc:92072 Proteins