Browse our anti-Cathepsin D (CTSD) Antibodies

Full name:: anti-Cathepsin D Antibodies (CTSD)

On www.antibodies-online.com are 343 Cathepsin D (CTSD) Antibodies from 34 different suppliers available. Additionally we are shipping Cathepsin D Kits (90) and Cathepsin D Proteins (54) and many more products for this protein. A total of 506 Cathepsin D products are currently listed.

Synonyms:: CatD, Cathd, CD, CLN10, CPSD, CTSD, DDBDRAFT_0205785, DDBDRAFT_0215012, DDB_0205785, DDB_0215012, DKFZp469J0315, fb93e11, fj17b09, LOC398557, LOC100136761, wu:fb93e11, wu:fj17b09

list all antibodies	Gene Name	GeneID	UniProt
	CTSD	1509	P07339
	CTSD	13033	P18242
	CTSD	171293
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Most Popular Reactivities for anti-Cathepsin D (CTSD) Antibodies

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anti-Human Cathepsin D Antibodies:

anti-Mouse (Murine) Cathepsin D Antibodies:

anti-Rat (Rattus) Cathepsin D Antibodies:

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Relevant Pathways for anti-Cathepsin D Antibodies

Peptide Hormone Metabolism

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Top referenced anti-Cathepsin D Antibodies

Human Monoclonal Cathepsin D Primary Antibody for IF, IP - ABIN968183 : Erickson, Conner, Blobel: Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D. in The Journal of biological chemistry 1981 (PubMed)
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Human Monoclonal Cathepsin D Primary Antibody for IF, IP - ABIN968184 : Faust, Kornfeld, Chirgwin: Cloning and sequence analysis of cDNA for human cathepsin D. in Proceedings of the National Academy of Sciences of the United States of America 1985 (PubMed)
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Human Monoclonal Cathepsin D Primary Antibody for ELISA, EM - ABIN269482 : Kitamura, Nakamura, Miyamoto, Miyamoto, Kabu, Yoshida, Futamura, Ichinose, Arakawa: Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria. in PLoS ONE 2011 (PubMed)
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Human Monoclonal Cathepsin D Primary Antibody for WB - ABIN1882228 : Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: Initial characterization of the human central proteome. in BMC systems biology 2011 (PubMed)
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Human Monoclonal Cathepsin D Primary Antibody for ELISA, EM - ABIN316063 : Miyamoto, Kitamura, Nakamura, Futamura, Miyamoto, Yoshida, Ono, Ichinose, Arakawa: Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control. in PLoS ONE 2011 (PubMed)
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Human Monoclonal Cathepsin D Primary Antibody for ELISA, WB - ABIN1582516 : Zhang, Zhang, Shea, Xu, Tobin, Knapton, Sharron, Rouse: Autophagy in pancreatic acinar cells in caerulein-treated mice: immunolocalization of related proteins and their potential as markers of pancreatitis. in Toxicologic pathology 2014 (PubMed)
Human Monoclonal Cathepsin D Primary Antibody for IHC (p), IP - ABIN560534 : Kam, Hennessy, Chua, Gan, Philp, Hon, Lai, Chan, Ong, Wong, Lim, Ling, Tan, Tan, Ho, Kon: Characterization of the human gastric fluid proteome reveals distinct pH-dependent protein profiles: implications for biomarker studies. in Journal of proteome research 2011 (PubMed)
Human Polyclonal Cathepsin D Primary Antibody for ELISA, IF (cc) - ABIN732098 : Liao, Li, Li, Liu: Organellar proteome analyses of ricin toxin-treated HeLa cells. in Toxicology and industrial health 2014 (PubMed)
Human Polyclonal Cathepsin D Primary Antibody for IP, WB - ABIN4288228 : Sethna, Chamakkala, Gu, Thompson, Cao, Elliott, Finnemann: Regulation of Phagolysosomal Digestion by Caveolin-1 of the Retinal Pigment Epithelium Is Essential for Vision. in The Journal of biological chemistry 2016 (PubMed)
Human Polyclonal Cathepsin D Primary Antibody for IHC, IHC (p) - ABIN4288229 : Ahmad, Boisvert, Lundberg, Uhlen, Lamond: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization. in Molecular & cellular proteomics : MCP 2012 (PubMed)

More Antibodies against Cathepsin D Interaction Partners

Zebrafish Cathepsin D (CTSD) interaction partners

Silk Worm Cathepsin D (CTSD) interaction partners

These results suggest that the ecdysone response elements are vital for activation of the promoter by 20-hydroxyecdysone (20E) in the larval fat body and further support the crucial role of ecdysone signaling to control cathepsin D gene transcription.

Human Cathepsin D (CTSD) interaction partners

Epithelial ovarian (EOC) cancer secreted Cathepsin D acts as an extracellular ligand and may play an important pro-angiogenic, and thus pro-metastatic, role by activating the omental microvasculature during EOC metastasis to the omentum.
Results show that lowering endogenous cathepsin D abundance induced senescence in HeLa cells, leading to reduced cell proliferation, impaired tumorigenesis in a mouse model, and increased permeability of lysosomal membrane and reactive oxygen species accumulation. These results suggest that CTSD is involved in cancer cells in maintaining lysosomal integrity, redox balance, and Nrf2 (show GABPA Antibodies) activity, thus promoting tumorigenesis.
Data suggest that, compared to control individuals, serum cathepsin-D levels are up-regulated in patients with T2DM-Y (young onset type 2 diabetes) with and without diabetic retinopathy. This study was conducted in India.
apoptosis is accompanied by degradation of the cysteine cathepsin inhibitor stefin B (StfB (show CSTB Antibodies)). CatD did not exhibit a crucial role in this step. However, this degradation was partially prevented through pre-incubation with the antioxidant N-acetyl cysteine
The lysosomal enzyme cathepsin D (CTSD) mediates the proteolytic cleavage of PSAP (show PSAP Antibodies) precursor into saposins A-D. Myc (show MYC Antibodies)-CLN3 (show CLN3 Antibodies) colocalized with CTSD and activity of CTSD decreased as myc (show MYC Antibodies)-CLN3 (show CLN3 Antibodies) expression increased, and clearly decreased under hyperosmotic conditions
Study demonstrate that PGRN (show GRN Antibodies) interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN (show GRN Antibodies) may modulate protein homeostasis. This could potentially explain the TDP-43 (show TARDBP Antibodies) aggregation observed in frontotemporal lobar degeneration with GRN (show GRN Antibodies) mutations.
The S-nitrosation of a non-catalytic cysteine residue in the lysosomal aspartyl protease cathepsin D (CTSD) inhibited proteolytic activation.
Secreted PGRN (show GRN Antibodies) is incorporated into cells via sortilin (show SORT1 Antibodies) or cation-independent mannose 6-phosphate receptor (show IGF2R Antibodies), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN (show GRN Antibodies) levels led to a cell-type-specific increase of insoluble TDP-43 (show TARDBP Antibodies). In the brain tissue of FTLD-TDP patients with PGRN (show GRN Antibodies) deficiency, CTSD and phosphorylated TDP-43 (show TARDBP Antibodies) accumulated in neurons
CTSD, in need of its catalytic activity, may promote proliferation in advanced glycation end products-treated human umbilical vein endothelial cells independent of the autophagy-lysosome pathway.
Cathepsin D facilitates the TRAIL-induced apoptosis of MDA-MB-231 breast cancer cells in enzymatic activity-dependent manner. Caspase-8 (show CASP8 Antibodies) and Bid (show BID Antibodies) proteins are the CD targets. The modulatory role of CD in cell response to TRAIL was also confirmed in another breast cancer cell line SKBR3.

Mouse (Murine) Cathepsin D (CTSD) interaction partners

Acid ceramidase (show ASAH1 Antibodies) inhibitor LCL521 targets lysosomes to activate cathepsin B (show CTSB Antibodies) and cathepsin D, resulting in interrupted autophagy and ER stress that culminates in myeloid-suppressor cell death.
Study demonstrate that PGRN (show GRN Antibodies) interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN (show GRN Antibodies) may modulate protein homeostasis. This could potentially explain the TDP-43 (show TARDBP Antibodies) aggregation observed in frontotemporal lobar degeneration with GRN (show GRN Antibodies) mutations.
These results suggested that Purkinje cells (PCs) were more vulnerable to CTSD deficiency in lysosomes than to autophagy impairment, and this vulnerability does not depend on the severity of axonal swelling.
Exposure of J774A.1 cells to HOCl or HOSCN resulted in a significant decrease in the activity of the Cys (show DNAJC5 Antibodies)-dependent cathepsins B and L, but not the Asp (show C3 Antibodies)-dependent cathepsin D.
these results suggest that inhibition of lysosomal proteases, such as CtsD, could be a new therapeutic approach to reduce renal fibrosis and slow progression of chronic kidney disease.
The neuroectoderm specific cathepsin D (Ctsd) knock-out mice survived about 5.5 days longer.
Data indicate that cathepsin D (CD) protein is elevated in the retinas of diabetic mice and serum of human patients with diabetic macular edema (DME).
This study demonistrated that Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Post-translational modifications drive CatD into the nucleus to cleave Histone 3 in the involuting mammary gland.
Increased lysosomal storage in CatD KO mice causes oxidative damage in brain pericytes, subsequently resulting in an increased vessel diameter and enhanced permeability of the BBB (show ALMS1 Antibodies).

Cow (Bovine) Cathepsin D (CTSD) interaction partners

Association of polymorphisms in calpain 1 (show CAPN1 Antibodies), (mu/I) large subunit, calpastatin (show CAST Antibodies), and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
findings strongly suggest a link between the lysosomal dysfunction of cathepsin D and the etiology of Alzheimer's disease

Pig (Porcine) Cathepsin D (CTSD) interaction partners

Rabbit Cathepsin D (CTSD) interaction partners

The effect of heavy metal cations on the activity of cathepsin D, was studied.

Cathepsin D (CTSD) Antigen Profile

Antigen Summary

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.

Alternative names and synonyms associated with Cathepsin D (CTSD)

cathepsin D (ctsd) antibody
cathepsin D (LOC398557) antibody
cathepsin D S homeolog (ctsd.S) antibody
cathepsin D (CatD) antibody
lysosomal aspartic protease (LOC5567565) antibody
cathepsin D (LOC100136761) antibody
cathepsin D (CTSD) antibody
cathepsin D (Cathd) antibody
cathepsin D (ctsD) antibody
cathepsin D (catd) antibody
cathepsin D (Ctsd) antibody
cathepsin D-like (LOC443060) antibody

CatD antibody
Cathd antibody
CD antibody
CLN10 antibody
CPSD antibody
CTSD antibody
DDBDRAFT_0205785 antibody
DDBDRAFT_0215012 antibody
DDB_0205785 antibody
DDB_0215012 antibody
DKFZp469J0315 antibody
fb93e11 antibody
fj17b09 antibody
LOC398557 antibody
LOC100136761 antibody
wu:fb93e11 antibody
wu:fj17b09 antibody

Protein level used designations for anti-Cathepsin D (CTSD) Antibodies

etID16901.18 , cathepsin D , aspartic protease , cathepsin d , preprocathepsin D , ceroid-lipofuscinosis, neuronal 10 , lysosomal aspartyl peptidase , lysosomal aspartyl protease , cathepsin D (lysosomal aspartyl peptidase) , cathepsin D (lysosomal aspartyl protease) , prepro-cathepsin D, prepro-CD

GENE ID	SPECIES
65225	Danio rerio
398557	Xenopus laevis
443721	Xenopus laevis
692768	Bombyx mori
5567565	Aedes aegypti
100136761	Oncorhynchus mykiss
100137367	Papio anubis
100168373	Acyrthosiphon pisum
100172401	Pongo abelii
8622052	Dictyostelium discoideum AX4
100528208	Ictalurus punctatus
1509	Homo sapiens
101094625	Felis catus
13033	Mus musculus
171293	Rattus norvegicus
282883	Bos taurus
483662	Canis lupus familiaris
494568	Sus scrofa
100101595	Oryctolagus cuniculus
100735735	Cavia porcellus
396090	Gallus gallus
443060	Ovis aries

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Show all anti-Cathepsin D (CTSD) Antibodies with Pubmed References