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Human Polyclonal CDX2 Primary Antibody for IHC (p), IP - ABIN151575
Verzi, Hatzis, Sulahian, Philips, Schuijers, Shin, Freed, Lynch, Dang, Brown, Clevers, Liu, Shivdasani: TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. in Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Monoclonal CDX2 Primary Antibody for FACS, ELISA - ABIN1724921
Lee, Vogt, Hsiao, Osunkoya: CDX-2 expression in malignant germ cell tumors of the testes, intratubular germ cell neoplasia, and normal seminiferous tubules. in Tumour biology 2012
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Human Monoclonal CDX2 Primary Antibody for ELISA, WB - ABIN1724918
Liu, Zhang, Zhan, Brock, Herman, Guo: CDX2 serves as a Wnt signaling inhibitor and is frequently methylated in lung cancer. in Cancer biology & therapy 2012
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Human Polyclonal CDX2 Primary Antibody for ELISA, WB - ABIN251330
Qualtrough, Hinoi, Fearon, Paraskeva: Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system. in Gut 2002
Human Monoclonal CDX2 Primary Antibody for ELISA, WB - ABIN560320
Zulueta, Caretti, Signorelli, Dallolio, Trinchera: Transcriptional control of the B3GALT5 gene by a retroviral promoter and methylation of distant regulatory elements. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
Cow (Bovine) Polyclonal CDX2 Primary Antibody for WB - ABIN2777319
Saad, Cho, Silverman, Liu: Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma. in American journal of clinical pathology 2004
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Human Monoclonal CDX2 Primary Antibody for IHC (p), IHC - ABIN152122
Flisikowska, Merkl, Landmann, Eser, Rezaei, Cui, Kurome, Zakhartchenko, Kessler, Wieland, Rottmann, Schmid, Schneider, Kind, Wolf, Saur, Schnieke: A porcine model of familial adenomatous polyposis. in Gastroenterology 2012
These results provide evidence that CDX2 plays an essential role in functional trophectoderm formation during primate embryonic development.
CDX2 is highly expressed along the atrophic gastritis-metaplasia-dysplasia-cancer sequential. Though CDX2 expression is quite dominant in IM ( intestinal metaplasia), but its expression is not associated with H. pylori (Helicobacter pylori) infection.
of CDX2 using a hypoxia-inducible hTERT promoter-driven vector suppressed malignant progression of colon cancer cells in vitro and in vivo.These results suggest that pLVX-5HRE-hTERTp-CDX2-3FLAG gene therapy may be a promising novel approach to treat colon cancer
The results of the present study show that a lack of CDX2 expression in metastatic colorectal cancer is an adverse prognostic feature and a potential negative predictor of the response to chemotherapy.
We may conclude that hTERT promotes GIM by up-regulating CDX2 via NF-kappaB (show NFKB1 Antibodies) signaling pathway.
Our work suggests that combination of the consensual CMS (show Cd2ap Antibodies) classification and lack of CDX2 expression could be a useful marker to identify CMS4/CDX2-negative patients with a very poor prognosis
AMPK (show PRKAA1 Antibodies) enhances intestinal barrier function and epithelial differentiation via promoting CDX2 expression, which is partially mediated by altered histone modifications in the Cdx2 promoter.
Findings suggest that H. pylori infectionis a driving force of gastric cardia carcinogenesis by upregulating caudal (show CAD Antibodies)-related homeobox (show Lbx1 Antibodies) transcription factor 2 (show HNF1B Antibodies) (CDX2) and inducing inflammation.
Data show that a two-marker panel of p40 (show IL9 Antibodies) (DeltaNp63) and CDX2 is highly sensitive and specific.
our findings demonstrated that MDR1 (show TBC1D9 Antibodies) expression is regulated by CDX2 and is related to drug resistance in ovarian mucinous adenocarcinoma.
The data presented provide a novel insight into how CDX2 is implicated in the transcriptional regulation of LAMC2 (show LAMC2 Antibodies) in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha (show TNF Antibodies) is present.
Data show that SLC7A7 (show Slc7a7 Antibodies) is a CDX2 target gene, and that CDX2 binds directly to the SLC7A7 (show Slc7a7 Antibodies) promoter.
these results provide further insight into the functional diversity of CDX2 in early mammalian embryos.
showed novel molecular regulation of CDX2 on Oct4 (show POU5F1 Antibodies), and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 (show POU5F1 Antibodies) in embryo of mammals other than mouse
Results reveal an early regulatory switch in Cdx2 expression and show that different inputs are needed to drive Cdx2 expression in the blastocyst trophectoderm and in trophoblast stem cells.
CDX2(Null)/BRAF (show BRAF Antibodies)(V600E) expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF (show BRAF Antibodies)(V600E) potently interacted with CDX2 silencing to alter gene expression. Like human serrated lesions, CDX2(Null)/BRAF (show BRAF Antibodies)(V600E)-mutant epithelium expressed gastric markers.
including Wnt (show WNT2 Antibodies) and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx (show CDX1 Antibodies)/Hox (show MSH2 Antibodies) and T Brachyury (show TBX1 Antibodies) transcriptional networks controls differential axial growth during vertebrate trunk elongation
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha (show HNF4A Antibodies) were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha (show HNF4A Antibodies) in human biopsy samples.
Cdx (show CDX1 Antibodies) members interact with the SWI (show SMARCA1 Antibodies)-SNF (show SNRPA Antibodies) complex and make direct contact with Brg1 (show SMARCA4 Antibodies), a catalytic member of SWI (show SMARCA1 Antibodies)-SNF (show SNRPA Antibodies). Both Cdx2 and Brg1 (show SMARCA4 Antibodies) co-occupy a number of Cdx (show CDX1 Antibodies) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 (show SMARCA4 Antibodies) occupancy occurs coincident with chromatin remodeling at some of these loci.
The authors identify a Cdx2-responsive segment of HoxA, immediately 5' to the recently defined regulatory domain orchestrating initial transcription of the first Hox (show MSH2 Antibodies) gene.
Cdx1 (show CDX1 Antibodies)-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac (show ADCY10 Antibodies) and a block in hematopoietic differentiation from yolk sac (show ADCY10 Antibodies)-derived cells in culture.
this study shows that Aloe vera (show IGF2BP3 Antibodies) gel suppresses colitis-related colon carcinogenesis via increased expression of CDX-2, a tumor suppressor in colorectal cancer
Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 (show HOXB7 Antibodies) and Cdx2 in colon cancer cells.
results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
caudal type homeobox 2
, caudal type homeobox transcription factor 2
, caudal type homeo box transcription factor 2
, homeobox protein CDX-2
, caudal-type homeobox protein 2
, caudal type homeo box 2
, caudal-type homeobox transcription factor 2