rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (N-Term) Peptide
ARHGEF4
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Quick Overview for rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (N-Term) Peptide (ABIN1541270)
Target
ARHGEF4
(rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- ADDYEAPRAG AREADDSGPE AQSCKDQMRT NVINEILSTE RDYIKHLRDI
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Arhgef4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) peptide
ARHGEF4 Reactivity: Human Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))
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Background
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Arhgef4 acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion By similarity. It is required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Arhgef4 is involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Alias Symbols: 9330140K16Rik, Asef, ENSMUSG00000070955
Protein Size: 484 -
Molecular Weight
- 57 kDa
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Gene ID
- 226970
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NCBI Accession
- NM_183019, NP_898840
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UniProt
- Q7TNR9
Target
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