Histamine Receptor H3 (HRH3) (N-Term) Peptide
HRH3
Reactivity: Human, Rat
Host: Synthetic
BP, WB
Catalog No. ABIN1541323
Quick Overview for Histamine Receptor H3 (HRH3) (N-Term) Peptide (ABIN1541323)
Target
HRH3
(Histamine Receptor H3 (HRH3))
Origin
Human, Rat
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- VFNIVLISYD RFLSVTRAVS YRAQQGDTRR AVRKMALVWV LAFLLYGPAI
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Hrh3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HRH3 (Histamine Receptor H3 (HRH3))
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Background
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This gene encodes a histamine H3 receptor that belongs to the superfamily of G-protein coupled receptors. This protein functions as a presynaptic autoreceptor on histamine neurons in the brain, and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. It is deemed a great target for the development of therapeutics for numerous disorders, including obesity, epilepsy, and such cognitive diseases as attention deficit hyperactivity disorder and Alzheimer's disease. Several alternatively spliced transcript variants encoding different isoforms, with different brain expression patterns and signaling properties, have been described for this gene.
Alias Symbols: -
Protein Size: 445 -
Molecular Weight
- 48 kDa
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Gene ID
- 85268
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NCBI Accession
- NM_053506, NP_445958
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UniProt
- Q9QYN8
Target
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