Sorting Nexin 15 (SNX15) (N-Term) Peptide
SNX15
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN1541460
Quick Overview for Sorting Nexin 15 (SNX15) (N-Term) Peptide (ABIN1541460)
Target
SNX15
(Sorting Nexin 15 (SNX15))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- RKLHGDLAYT HRNLFRRLEE FPAFPRAQVF GRFEASVIEE RRKGAEDLLR
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SNX15 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SNX15 (Sorting Nexin 15 (SNX15))
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Background
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This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.
Alias Symbols: HSAF001435
Protein Size: 256 -
Molecular Weight
- 29 kDa
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Gene ID
- 29907
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NCBI Accession
- NM_147777, NP_680086
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UniProt
- E5KQS6
Target
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