Granulin (GRN) (Middle Region) Peptide
GRN
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN2182618
Quick Overview for Granulin (GRN) (Middle Region) Peptide (ABIN2182618)
Target
Granulin (GRN)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- Middle Region
-
Sequence
- CPMPNATCCS DHLHCCPQDT VCDLIQSKCL SKENATTDLL TKLPAHTVGD
-
Characteristics
- This is a synthetic peptide designed for use in combination with anti-GRN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
-
-
Application Notes
- Optimal working dilution should be determined by the investigator.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handling Advice
- Avoid repeat freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- Granulin (GRN)
-
Target Type
- Viral Protein
-
Background
-
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Alias Symbols: CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Protein Size: 438 -
Molecular Weight
- 48 kDa
-
Gene ID
- 2896
-
NCBI Accession
- NM_002087, NP_002078
Target
-
You are here:
