Sestrin 1 (SESN1) (Middle Region) Peptide
SESN1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN2183911
Quick Overview for Sestrin 1 (SESN1) (Middle Region) Peptide (ABIN2183911)
Target
SESN1
(Sestrin 1 (SESN1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- KWLNGLENAP QKLQNLGELN KVLAHRPWLI TKEHIEGLLK AEEHSWSLAE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SESN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SESN1 (Sestrin 1 (SESN1))
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Background
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This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alias Symbols: PA26, SEST1
Protein Size: 551 -
Molecular Weight
- 64 kDa
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Gene ID
- 27244
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NCBI Accession
- NM_014454, NP_055269
Target
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