Unc-13 Homolog D (UNC13D) (C-Term) Peptide
UNC13D
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN2184174
Quick Overview for Unc-13 Homolog D (UNC13D) (C-Term) Peptide (ABIN2184174)
Target
UNC13D
(Unc-13 Homolog D (UNC13D))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- SGSEEPGEVP QTRLPLTYPA PNGDPILQLL EGRKGDREAQ VFVRLRRHRA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-UNC13D Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- UNC13D (Unc-13 Homolog D (UNC13D))
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Background
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This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Alias Symbols: FHL3, HLH3, HPLH3, Munc13-4
Protein Size: 1090 -
Molecular Weight
- 119 kDa
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Gene ID
- 201294
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NCBI Accession
- NM_199242, NP_954712
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UniProt
- Q70J99
Target
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