Lysine (K)-Specific Demethylase 2A (KDM2A) (Middle Region) Peptide
KDM2A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN2184592
Quick Overview for Lysine (K)-Specific Demethylase 2A (KDM2A) (Middle Region) Peptide (ABIN2184592)
Target
KDM2A
(Lysine (K)-Specific Demethylase 2A (KDM2A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- LTPPADKPGQ DNRSKLRNMT DFRLAGLDIT DATLRLIIRH MPLLSRLDLS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-KDM2A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- KDM2A (Lysine (K)-Specific Demethylase 2A (KDM2A))
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Background
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3.
Alias Symbols: CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
Protein Size: 620 -
Molecular Weight
- 68 kDa
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Gene ID
- 22992
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NCBI Accession
- NM_012308, NP_036440
Target
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