Ring Finger Protein 216 (RNF216) (N-Term) Peptide
RNF216
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN2185638
Quick Overview for Ring Finger Protein 216 (RNF216) (N-Term) Peptide (ABIN2185638)
Target
RNF216
(Ring Finger Protein 216 (RNF216))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- IVNPRLEQKV IILGENGLLF PESEPLEVQN QSSEDSETEL LSNPGEPAAS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Rnf216 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RNF216 (Ring Finger Protein 216 (RNF216))
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Background
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Rnf216 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. It promotes degradation of TRAF3, TLR4 and TLR9. It contributes to the regulation of antiviral responses. It down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production and promotes TNF and RIP mediated apoptosis.
Protein Size: 853 -
Molecular Weight
- 93 kDa
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Gene ID
- 108086
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UniProt
- P58283
Target
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