Growth Differentiation Factor 5 (GDF5) (Middle Region) Peptide
GDF5
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GDF5 products
- GDF5 (Growth Differentiation Factor 5 (GDF5))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- DEPKKLPPRP GGPEPKPGHP PQTRQATART VTPKGQLPGG KAPPKAGSVP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- GDF5 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GDF5 (Growth Differentiation Factor 5 (GDF5))
- Background
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The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. These associations confirm that this gene product plays a role in skeletal development. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Alias Symbols: OS5, LAP4, BDA1C, BMP14, CDMP1, LAP-4, SYM1B, SYNS2, BMP-14
Protein Size: 501 - Gene ID
- 8200
- NCBI Accession
- NM_000557, NP_000548
- UniProt
- P43026
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