Dual Oxidase 1 (DUOX1) (N-Term) Peptide
DUOX1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511144
Quick Overview for Dual Oxidase 1 (DUOX1) (N-Term) Peptide (ABIN5511144)
Target
DUOX1
(Dual Oxidase 1 (DUOX1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- LLVGAWTPLG AQNPISWEVQ RFDGWYNNLM EHRWGSKGSR LQRLVPASYA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- DUOX1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DUOX1 (Dual Oxidase 1 (DUOX1))
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Background
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The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
Alias Symbols: LNOX1, THOX1, NOXEF1
Protein Size: 1551 -
Gene ID
- 53905
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NCBI Accession
- NM_017434, NP_059130
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UniProt
- Q9NRD9
Target
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