Histamine Receptor H1 (HRH1) (C-Term) Peptide
HRH1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511281
Quick Overview for Histamine Receptor H1 (HRH1) (C-Term) Peptide (ABIN5511281)
Target
HRH1
(Histamine Receptor H1 (HRH1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- SSWPSPTEPS SKSGNLRHLH ILIGTSVVKI PFTILLFFLL HRWCSNKKKC
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HRH1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HRH1 (Histamine Receptor H1 (HRH1))
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Background
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Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Alias Symbols: H1R, H1-R, HH1R, hisH1
Protein Size: 487 -
Gene ID
- 3269
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NCBI Accession
- NM_000861, NP_000852
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UniProt
- P35367
Target
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