Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B) (Middle Region) Peptide
IDH3B
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511311
$160.46
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100 μg
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Quick Overview for Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B) (Middle Region) Peptide (ABIN5511311)
Target
IDH3B
(Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- RRKLDLFANV VHVKSLPGYM TRHNNLDLVI IREQTEGEYS SLEHESARGV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- IDH3B Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IDH3B (Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B))
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Background
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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: RP46, H-IDHB
Protein Size: 385 -
Gene ID
- 3420
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NCBI Accession
- NM_006899, NP_008830
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UniProt
- O43837
Target
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