Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3) (Middle Region) Peptide
UCP3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511377
Quick Overview for Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3) (Middle Region) Peptide (ABIN5511377)
Target
UCP3
(Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- CTTGAMAVTC AQPTDVVKVR FQASIHLGPS RSDRKYSGTM DAYRTIAREE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- UCP3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))
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Background
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Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression, this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.
Alias Symbols: SLC25A9
Protein Size: 275 -
Gene ID
- 7352
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NCBI Accession
- NM_003356, NP_003347
Target
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