Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (N-Term) Peptide
APEX1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511766
Quick Overview for Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (N-Term) Peptide (ABIN5511766)
Target
APEX1
(Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- SKTAAKKNDK EAAGEGPALY EDPPDQKTSP SGKPATLKIC SWNVDGLRAW
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-APEX1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
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Background
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene, all encode the same protein.
Alias Symbols: APEX1,APE, APE1, APEX, APX, HAP1, REF1,
Protein Size: 318 -
Gene ID
- 328
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NCBI Accession
- XP_005267638
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UniProt
- P27695
Target
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