Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (Middle Region) Peptide
APEX1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all APEX1 products
- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- HEEIDLRNPK GNKKNAGFTP QERQGFGELL QAVPLADSFR HLYPNTPYAY
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-APEX1 Antibody(ARP58028_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
- Synonyms
- apex1 Peptide, MGC76280 Peptide, MGC79645 Peptide, MGC78928 Peptide, APE Peptide, APE1 Peptide, APEN Peptide, APEX Peptide, APX Peptide, HAP1 Peptide, REF1 Peptide, Apex Peptide, REF-1 Peptide, BAP1 Peptide, apex1a Peptide, hm:zehn1532 Peptide, wu:fc13d11 Peptide, zgc:66204 Peptide, Ref-1 Peptide, apurinic/apyrimidinic endodeoxyribonuclease 1 Peptide, APEX nuclease (multifunctional DNA repair enzyme) 1 Peptide, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog Peptide, DNA-(apurinic or apyrimidinic site) lyase Peptide, apurinic/apyrimidinic endonuclease 1 Peptide, APEX1 Peptide, apex1 Peptide, apex1.L Peptide, CNG03640 Peptide, CNH01280 Peptide, nth Peptide, Spirs_4119 Peptide, Palpr_0103 Peptide, Apex1 Peptide
- Background
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene, all encode the same protein.
Alias Symbols: APE, APE1, APEN, APEX, APX, HAP1, REF-1, REF1
Protein Interaction Partner: CDKN1A,MUTYH,TP53,ANP32A,ANP32C,APEX1,CSNK2A1,DCTN1,EP300,FEN1,GZMA,HDAC1,HIF1A,HMGB2,HNRNPL,HSPA1A,MUTYH,NME1,NXF2,PCNA,POLB,SET,TP53,TXN,UBE2I,XRCC1,XRCC6,ANP32A,FEN1,HIF1A,HNRNPL,MUTYH,PCNA,SET,TP53,XRCC1,XRCC5
Protein Size: 318 - Molecular Weight
- 35 kDa
- Gene ID
- 328
- NCBI Accession
- NM_001641, NP_001632
- UniProt
- P27695
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