Agouti Signaling Protein (ASIP) (Middle Region) Peptide
ASIP
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511781
Quick Overview for Agouti Signaling Protein (ASIP) (Middle Region) Peptide (ABIN5511781)
Target
ASIP
(Agouti Signaling Protein (ASIP))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- CFFTANSHLP PEEKLRDDRS LRSNSSVNLL DVPSVSIVAL NKKSKQIGRK
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- ASIP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ASIP (Agouti Signaling Protein (ASIP))
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Background
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In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
Alias Symbols: ASP, AGSW, AGTI, AGTIL, SHEP9
Protein Size: 132 -
Gene ID
- 434
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NCBI Accession
- NM_001672, NP_001663
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UniProt
- P42127
Target
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