Poly A Specific Ribonuclease (PARN) (Middle Region) Peptide
PARN
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PARN products
- PARN (Poly A Specific Ribonuclease (PARN))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- CQSSSIDFLA SQGFDFNKVF RNGIPYLNQE EERQLREQYD EKRSQANGAG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PARN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PARN (Poly A Specific Ribonuclease (PARN))
- Background
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The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DAN, DKCB6, PFBMFT4
Protein Size: 639 - Gene ID
- 5073
- NCBI Accession
- NM_001134477, NP_001127949
- UniProt
- O95453
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