Importin 5 (IPO5) (Middle Region) Peptide
IPO5
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Importin 5 (IPO5) products
- Importin 5 (IPO5)
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ ISYMISAWAR MCKILGKEFQ
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-IPO5 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Importin 5 (IPO5)
- Background
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Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
Alias Symbols: IMB3, Pse1, imp5, KPNB3, RANBP5
Protein Size: 1097 - Gene ID
- 3843
- NCBI Accession
- NM_002271
- UniProt
- O00410
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