Cold Inducible RNA Binding Protein (CIRBP) (Middle Region) Peptide
CIRBP
Reactivity: Human
Host: Synthetic
BP, WB
Quick Overview for Cold Inducible RNA Binding Protein (CIRBP) (Middle Region) Peptide (ABIN5512043)
Target
CIRBP
(Cold Inducible RNA Binding Protein (CIRBP))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CIRBP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CIRBP (Cold Inducible RNA Binding Protein (CIRBP))
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Background
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CIRBP is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. It acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
Alias Symbols: CIRBP,A18HNRNP,CIRP,
Protein Size: 172 -
Gene ID
- 1153
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NCBI Accession
- NP_001271
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UniProt
- Q14011
Target
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