Gonadotropin-Releasing Hormone Receptor (GNRHR) (C-Term) Peptide
GNRHR
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GNRHR products
- GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ICNAKIIFTL TRVLHQDPHE LQLNQSKNNI PRARLKTLKM TVAFATSFTV
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GNRHR Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))
- Background
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This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
Alias Symbols: HH7, GRHR, LRHR, LHRHR, GNRHR1
Protein Size: 328 - Gene ID
- 2798
- NCBI Accession
- NM_000406, NP_000397
- UniProt
- P30968
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